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These patients had lower CD8+% and higher CD4+:CD8+ ratios ( p \u2a7d 0.01) than non-HZ matched controls. Two patients with relapsing-remitting MS developed HZ twice while on NTZ. These findings underscore the importance of pre-NTZ HZ vaccination due to potential HZ risk.<\/jats:p>","DOI":"10.1177\/13524585241260537","type":"journal-article","created":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T23:31:30Z","timestamp":1718580690000},"page":"1370-1373","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Altered lymphocyte profiles and herpes zoster infections in patients with multiple sclerosis on natalizumab"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3202-6921","authenticated-orcid":false,"given":"Alexandra","family":"Balshi","sequence":"first","affiliation":[{"name":"Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nova","family":"Manning","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7465-5749","authenticated-orcid":false,"given":"John","family":"Dempsey","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin","family":"Kumbar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursela","family":"Baber","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0028-3031","authenticated-orcid":false,"given":"Jacob A","family":"Sloane","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,6,16]]},"reference":[{"key":"bibr1-13524585241260537","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044397"},{"key":"bibr2-13524585241260537","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2016.07.012"},{"key":"bibr3-13524585241260537","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12067"},{"key":"bibr4-13524585241260537","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.102838"},{"key":"bibr5-13524585241260537","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517711569"},{"key":"bibr6-13524585241260537","doi-asserted-by":"publisher","DOI":"10.1177\/13524585231189641"},{"key":"bibr7-13524585241260537","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1262-8"},{"key":"bibr8-13524585241260537","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510392263"},{"key":"bibr9-13524585241260537","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04897-2"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585241260537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585241260537","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585241260537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:15:30Z","timestamp":1777695330000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585241260537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,16]]},"references-count":9,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1177\/13524585241260537"],"URL":"https:\/\/doi.org\/10.1177\/13524585241260537","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,16]]}}}