{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:02:44Z","timestamp":1782273764634,"version":"3.54.5"},"reference-count":12,"publisher":"SAGE Publications","issue":"11-12","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>While John Cunningham virus (JCV) is known to cause neuronal damage in progressive multifocal leukoencephalopathy (PML) among natalizumab-treated MS patients, its association with axonal loss in non-PML conditions remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a cohort of 128 natalizumab-treated MS patients, serum neurofilament (sNfL) levels and JCV antibody titres were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 128 patients (mean age\u2009=\u200938.4\u2009years, 71.9% female), 51 (40%) were JCV positive. NfL levels increased by 15.3% for JCV index &lt;0.7 (95% confidence interval [CI]\u2009=\u20090.963\u20131.381), by 18.6% for index 0.7\u20131.5 (95% CI\u2009=\u20091.009\u20131.394) and by 21.1% for index &gt;1.5 (95% CI\u2009=\u20091.040\u20131.409) compared to JCV negative patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings indicate a potential link between JCV burden and neuroaxonal degeneration in natalizumab-treated MS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585241260977","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T02:06:10Z","timestamp":1718417170000},"page":"1561-1565","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Neuroaxonal damage in natalizumab-treated MS patients: The role of JCV antibody titres"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8761-9337","authenticated-orcid":false,"given":"Gloria","family":"Dalla Costa","sequence":"first","affiliation":[{"name":"Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9326-6753","authenticated-orcid":false,"given":"Letizia","family":"Leocani","sequence":"additional","affiliation":[{"name":"Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pisa","sequence":"additional","affiliation":[{"name":"Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Croese","sequence":"additional","affiliation":[{"name":"Neuroimmunology Research Unit, San Raffaele Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Department of Neurology, San Raffaele Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6313-4952","authenticated-orcid":false,"given":"Lucia","family":"Moiola","sequence":"additional","affiliation":[{"name":"Department of Neurology, San Raffaele Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Sangalli","sequence":"additional","affiliation":[{"name":"Department of Neurology, San Raffaele Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Colombo","sequence":"additional","affiliation":[{"name":"Department of Neurology, San Raffaele Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiden","family":"Haghikia","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Gold","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7376-9425","authenticated-orcid":false,"given":"Roberto","family":"Furlan","sequence":"additional","affiliation":[{"name":"Neuroimmunology Research Unit, San Raffaele Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Comi","sequence":"additional","affiliation":[{"name":"Vita-Salute San Raffaele University, Milan, Italy\/Multiple Sclerosis Center, Casa di Cura Igea, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"bibr1-13524585241260977","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044397"},{"key":"bibr2-13524585241260977","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000158329.30470.D0"},{"key":"bibr3-13524585241260977","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24286"},{"key":"bibr4-13524585241260977","doi-asserted-by":"publisher","DOI":"10.1177\/1352458515599681"},{"key":"bibr5-13524585241260977","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107829"},{"key":"bibr6-13524585241260977","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25437"},{"key":"bibr7-13524585241260977","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.02.002"},{"key":"bibr8-13524585241260977","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.10.5726-5734.1992"},{"key":"bibr9-13524585241260977","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25523"},{"key":"bibr10-13524585241260977","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009571"},{"key":"bibr11-13524585241260977","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad374"},{"key":"bibr12-13524585241260977","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30069-3"}],"container-title":["Multiple 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