{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:09:29Z","timestamp":1790140169083,"version":"4.0.1"},"reference-count":35,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS109023"],"award-info":[{"award-number":["R01NS109023"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We examined whether brain hemodynamic responses, gait, and cognitive performances under single- and dual-task conditions predict falls during longitudinal follow-up in older adults with multiple sclerosis (OAMS) with relapsing-remitting and progressive subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Participants with relapsing-remitting (\n                      <jats:italic>n<\/jats:italic>\n                      = 53, mean age = 65.02 \u00b1 4.17 years, %female = 75.5) and progressive (\n                      <jats:italic>n<\/jats:italic>\n                      = 28, mean age = 64.64 \u00b1 4.31 years, %female = 50) multiple sclerosis (MS) subtypes completed a dual-task-walking paradigm and reported falls during longitudinal follow-up using a monthly structured telephone interview. We used functional near-infrared spectroscopy (fNIRS) to assess oxygenated hemoglobin (HbO) in the prefrontal cortex during active walking and while performing a cognitive test under single- and dual-task conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Adjusted general estimating equations models indicated that higher HbO under dual-task walking was significantly associated with a reduction in the odds of reporting falls among participants with relapsing-remitting (odds ratio (OR) = 0.472,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004, 95% confidence interval (CI) = 0.284\u20130.785), but not progressive (OR = 1.056,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.792, 95% CI = 0.703\u20131.588) MS. In contrast, faster stride velocity under dual-task walking was significantly associated with a reduction in the odds of reporting falls among progressive (OR = 0.658,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004, 95% CI = 0.495\u20130.874), but not relapsing-remitting (OR = 0.998,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.995, 95% CI = 0.523\u20131.905) MS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Findings suggest that higher prefrontal cortex activation levels during dual-task walking, which may represent compensatory reallocation of brain resources, provide protection against falls for OAMS with relapsing-remitting subtype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585241277400","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T21:33:03Z","timestamp":1726263183000},"page":"1664-1673","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Brain hemodynamic responses and fall prediction in older adults with multiple sclerosis"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6639-0724","authenticated-orcid":false,"given":"Roee","family":"Holtzer","sequence":"first","affiliation":[{"name":"The Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA"},{"name":"Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1529-8842","authenticated-orcid":false,"given":"Frederick W","family":"Foley","sequence":"additional","affiliation":[{"name":"Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA"},{"name":"Multiple Sclerosis Center, Holy Name Medical Center, Teaneck, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5894-2290","authenticated-orcid":false,"given":"Robert W","family":"Motl","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2258-6933","authenticated-orcid":false,"given":"Mark E","family":"Wagshul","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3501-9508","authenticated-orcid":false,"given":"Manuel E","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Community Health, College of Applied Health Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA"},{"name":"Department of Biomedical and Translational Sciences, Carle Illinois College of Medicine, University of Illinois Urbana-Champaign, Urbana, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L","family":"Lipton","sequence":"additional","affiliation":[{"name":"Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA"},{"name":"Department of Biomedical Engineering, Columbia University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann","family":"Picone","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center, Holy Name Medical Center, Teaneck, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meltem","family":"Izzetoglu","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Villanova University, Villanova, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514538884"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269215513517575"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2013.08.244"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20120231"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1080\/09638288.2020.1786173","article-title":"Fall definitions, faller classifications and outcomes used in falls research among people with multiple sclerosis: A systematic review","volume":"44","author":"O\u2019Malley N","year":"2022","unstructured":"O\u2019Malley N, Clifford AM, Comber L, et al. 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