{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:00:07Z","timestamp":1793397607115,"version":"4.5.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>People with multiple sclerosis (PwMS) have an increased cardiovascular and cerebrovascular disease burden, but this could be mitigated by vascular risk factor management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We compared the trajectories of vascular risk factors, vascular comorbidities and clinical management in PwMS against the general population post-MS diagnosis while controlling for frailty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective longitudinal analysis using English data from the Clinical Practice Research Datalink between 1987 and 2018 comprising PwMS matched with up to six controls without MS by age, sex and general practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We compared 12,251 PwMS with 72,572 matched controls; 3.8% of PwMS had mild\u2013moderate frailty, 1.2% more than matched controls. Compared to controls, PwMS had an elevated incidence of Type 2 diabetes (HR 1.18, 95% CI (1.04, 1.34)), and starting antihypertensive medications (HR 1.40, 95% CI (1.33, 1.47)). Among those with hypertension at baseline, blood pressure trajectories did not differ between PwMS and controls. PwMS had increased rates of meeting targets for hypertension management (HR 1.25, 95% CI (1.12, 1.41)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The observation that PwMS with hypertension are more likely to meet treatment targets than matched controls is encouraging, but the elevated rates of vascular comorbidities suggest that tighter vascular management may be needed in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585241287388","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T02:07:49Z","timestamp":1729217269000},"page":"1653-1663","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Trajectories and management of vascular risk following the diagnosis of multiple sclerosis: A population-based matched cohort study between 1987 and 2018 in England"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3437-812X","authenticated-orcid":false,"given":"Raffaele","family":"Palladino","sequence":"first","affiliation":[{"name":"Department of Primary Care and Public Health, School of Public Health, Imperial College London, London, UK"},{"name":"Department of Public Health, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Chataway","sequence":"additional","affiliation":[{"name":"Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK"},{"name":"University College London Hospitals Biomedical Research Centre, National Institute for Health Research, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mekha","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Public Health, School of Public Health, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azeem","family":"Majeed","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Public Health, School of Public Health, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1855-5595","authenticated-orcid":false,"given":"Ruth Ann","family":"Marrie","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.0664"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.101987"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002481"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514564491"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000230"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458516650512"},{"key":"e_1_3_2_8_2","volume-title":"Cardiovascular disease: Risk assessment and reduction, including lipid modification","author":"National Institute for Health and Care Excellence (NICE)","year":"2014","unstructured":"National Institute for Health and Care Excellence (NICE). Cardiovascular disease: Risk assessment and reduction, including lipid modification. London: National Institute for Health and Care Excellence, 2014."},{"key":"e_1_3_2_9_2","unstructured":"National Institute for Health and Care Excellence (NICE). Cardiovascular disease prevention https:\/\/www.nice.org.uk\/guidance\/ph25 (2014 accessed 2 July 2024)."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585231164296"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)62167-9"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02675-9"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-018-0772-2"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-021-00029-9"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520923945"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520987541"},{"key":"e_1_3_2_17_2","unstructured":"CPRD. Clinical practice research link https:\/\/www.cprd.com (2023 accessed 20 February 2023)."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv098"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdt116"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.14236\/jhi.v24i3.942"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.7861\/futurehosp.5-3-207"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012610"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007043"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1214\/09-STS313"},{"key":"e_1_3_2_25_2","unstructured":"GOV.UK. English indices of deprivation 2015 https:\/\/www.gov.uk\/government\/statistics\/english-indices-of-deprivation-2015 (2015 accessed 20 February 2023)."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy194"},{"key":"e_1_3_2_27_2","volume-title":"Hypertension in adults: Diagnosis and management","author":"National Institute for Health and Care Excellence (NICE)","year":"2023","unstructured":"National Institute for Health and Care Excellence (NICE). Hypertension in adults: Diagnosis and management. London: National Institute for Health and Care Excellence, 2023."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585221074010"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517694432"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001187"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181c1ea43"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12720"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311429"},{"key":"e_1_3_2_34_2","unstructured":"NHS. Diagnosis \u2013Multiple sclerosis https:\/\/www.nhs.uk\/conditions\/multiple-sclerosis\/diagnosis\/#:~:text=Your%20neurologist%20will%20look%20for way%20that%20might%20suggest%20MS (accessed 26 January 2023)."},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585211019243"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa255"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585241287388","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585241287388","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585241287388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:16:28Z","timestamp":1777695388000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585241287388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,17]]},"references-count":35,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1177\/13524585241287388"],"URL":"https:\/\/doi.org\/10.1177\/13524585241287388","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,17]]}}}