{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:44:41Z","timestamp":1781135081905,"version":"3.54.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100007379","name":"Fondation pour l'Aide \u00e0 la Recherche sur la Scl\u00e9rose en Plaques","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007379","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Previous studies have shown that people with multiple sclerosis (MS) had frequent healthcare visits up to 10 years before being diagnosed but with no information from magnetic resonance imaging (MRI) scans of the connection with the radiologically isolated syndrome (RIS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To analyze healthcare use 3 years before the RIS diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We examined healthcare usage before the first scan in RIS cases from 2010 to 2019. RIS subjects were identified from the French National MS observatory and compared to the general population (matched 10:1) and MS patients (matched 4:1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 482 RIS individuals, 223 (46.3%) were not linked to the healthcare resources database. The remaining RIS individuals (53.7%) had higher healthcare usage before their RIS diagnosis for issues related to neurology visits, headaches (odds ratio (OR): 3.34, confidence interval (CI): [2.00\u20135.57], p &lt; 0.0001), and the use of anti-migraine drugs (OR: 2.61, CI: [1.37\u20134.99], p = 0.004) compared to MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Only about half of RIS patients had MS-selected healthcare resources, which allowed for data linkage. Those who did seek care before their RIS diagnosis were most commonly known for other neurological comorbidities. These findings do not support the idea of a systemic prodrome before RIS diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585241291471","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T01:55:13Z","timestamp":1736560513000},"page":"184-196","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of healthcare utilization before the diagnosis of radiologically isolated syndrome"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3713-2416","authenticated-orcid":false,"given":"Christine","family":"Lebrun-Frenay","sequence":"first","affiliation":[{"name":"CRCSEP Neurology, CHU Nice, UR2CA-URRIS, Universit\u00e9 Nice Cote d\u2019Azur, H\u00f4pital Pasteur2, Nice, France; CRCSEP Nice, Neurologie CHU de Nice Pasteur 2, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4119-203X","authenticated-orcid":false,"given":"Sandrine","family":"Kerbrat","sequence":"additional","affiliation":[{"name":"DAMAD Plouzan\u00e9, Plouzan\u00e9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6499-1523","authenticated-orcid":false,"given":"Darin T","family":"Okuda","sequence":"additional","affiliation":[{"name":"The University of Texas Southwestern Medical Center, Dallas, TX, USA"},{"name":"Peter O\u2019Donnell Jr. Brain Institute, The University of Texas Southwestern Medical Center, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0622-8708","authenticated-orcid":false,"given":"Cassandre","family":"Landes-Chateau","sequence":"additional","affiliation":[{"name":"UR2CA-URRIS, Universit\u00e9 Nice C\u00f4te d\u2019Azur, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhun H","family":"Kantarci","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2702-3343","authenticated-orcid":false,"given":"Chloe","family":"Pierret","sequence":"additional","affiliation":[{"name":"Rennes University, EHESP, CNRS, Inserm, ARENES UMR 6051, RSMS U 1309, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwan","family":"Drezen","sequence":"additional","affiliation":[{"name":"CUBR Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Nowak","sequence":"additional","affiliation":[{"name":"DAMAD Plouzan\u00e9, Plouzan\u00e9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8340-6641","authenticated-orcid":false,"given":"Aksel","family":"Siva","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Istanbul University Cerrahpasa, Istanbul, Turky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8622-1845","authenticated-orcid":false,"given":"Christina J","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3985-1297","authenticated-orcid":false,"given":"Mikael","family":"Cohen","sequence":"additional","affiliation":[{"name":"CRCSEP Neurology, CHU Nice, UR2CA-URRIS, Universit\u00e9 Nice Cote d\u2019Azur, H\u00f4pital Pasteur2, Nice, France; CRCSEP Nice, Neurologie CHU de Nice Pasteur 2, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8424-4499","authenticated-orcid":false,"given":"Emmanuelle","family":"Leray","sequence":"additional","affiliation":[{"name":"Rennes University, EHESP, CNRS, Inserm, ARENES UMR 6051, RSMS U 1309, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"bibr1-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000335764.14513.1a"},{"key":"bibr2-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.28271"},{"key":"bibr3-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090509"},{"key":"bibr4-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25799"},{"key":"bibr5-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512471877"},{"key":"bibr6-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30076-5"},{"key":"bibr7-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25247"},{"key":"bibr8-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012074"},{"key":"bibr9-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207981"},{"key":"bibr10-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207843"},{"key":"bibr11-13524585241291471","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.1017492"},{"key":"bibr12-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518815602"},{"key":"bibr13-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1016\/j.respe.2017.05.004"},{"key":"bibr14-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"bibr15-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000471"},{"key":"bibr16-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00281-8"},{"key":"bibr17-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24564"},{"key":"bibr18-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200156"},{"key":"bibr19-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000395"},{"key":"bibr20-13524585241291471","author":"Montalban","journal-title":"Mult Sclerosis J"},{"key":"bibr21-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"bibr22-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad073"},{"key":"bibr23-13524585241291471","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.761408"},{"key":"bibr24-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.2.232"},{"key":"bibr25-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-11953-2"},{"key":"bibr26-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00148-5"},{"key":"bibr27-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1177\/13524585221122207"},{"key":"bibr28-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26555"},{"key":"bibr29-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.2815"},{"key":"bibr30-13524585241291471","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-022-00686-x"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585241291471","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585241291471","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585241291471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:16:35Z","timestamp":1777695395000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585241291471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,10]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1177\/13524585241291471"],"URL":"https:\/\/doi.org\/10.1177\/13524585241291471","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,10]]}}}