{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:33:28Z","timestamp":1791923608017,"version":"4.3.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Danish Multiple Sclerosis Society"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Teriflunomide has been associated with an increased risk of hypertension. Real-world studies including adequate control groups are lacking. We hypothesized that patients with multiple sclerosis (MS) treated with teriflunomide would be at higher risk of developing hypertension than those treated with dimethyl fumarate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a cohort study linking the Danish Multiple Sclerosis Registry with national health registries during a 10-year period. Teriflunomide ( N = 2656) and dimethyl fumarate ( N = 2237) exposure was defined by the first treatment record lasting \u2a7e 3 months, at which time follow-up started. We included 4893 adult patients without hypertension at baseline. Hypertension was defined as an International Classification of Diseases 10th Revision code for hypertension and by dispensed prescription drugs identified by the respective Anatomical Therapeutic Chemical codes. We used multivariable-adjusted Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We found 40.6 (teriflunomide) and 13.1 (dimethyl fumarate) hypertension events per 1000 person-years. Compared to dimethyl fumarate-treated patients, patients treated with teriflunomide had a higher risk of developing hypertension (adjusted hazard ratio = 2.80; 95% confidence interval = 2.19\u20133.56). The number needed to harm was 16 and 9 at 3 and 5 years of follow-up, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We found an increased risk of hypertension in adult patients with MS treated with teriflunomide.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585241299715","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T02:11:36Z","timestamp":1733364696000},"page":"36-43","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk of hypertension in patients with multiple sclerosis treated with teriflunomide compared to dimethyl fumarate: A nationwide cohort study in Denmark"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5702-3954","authenticated-orcid":false,"given":"Elisabeth","family":"Framke","sequence":"first","affiliation":[{"name":"The Danish Multiple Sclerosis Registry, Department of Neurology, Copenhagen University Hospital\u2014Rigshospitalet, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"Sellebjerg","sequence":"additional","affiliation":[{"name":"Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital\u2014Rigshospitalet, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kant","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital of Southern Jutland, University of Southern Denmark, Aabenraa, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Stilund","sequence":"additional","affiliation":[{"name":"Department of Neurology, Physiotherapy and Occupational Therapy, G\u00f8dstrup Hospital, Herning, Denmark"},{"name":"NIDO Centre for Research and Education, G\u00f8dstrup Hospital, Herning, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Boye","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Brain and Nerve Diseases, Lillebaelt Hospital, Kolding, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Illes","sequence":"additional","affiliation":[{"name":"Department of Neurology, Odense University Hospital, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasrin","family":"Asgari","sequence":"additional","affiliation":[{"name":"Department of Neurology, Slagelse Hospital, Slagelse, Denmark"},{"name":"Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark"},{"name":"Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Sejbaek","sequence":"additional","affiliation":[{"name":"Esbjerg Hospital, University Hospital of Southern Denmark, Esbjerg, Denmark"},{"name":"Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena Christina","family":"Roug","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zealand University Hospital, Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Broksgaard","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Northern Sealand, Hiller\u00f8d, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Aalborg University Hospital, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Vestergaard","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeppe Romme","family":"Christensen","sequence":"additional","affiliation":[{"name":"Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital\u2014Rigshospitalet, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkadiusz","family":"Weglewski","sequence":"additional","affiliation":[{"name":"Department of Neurology, Herlev-Gentofte Hospital, Herlev, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and 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Soelberg","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet Glostrup, Valdemar Hansens Vej 13, 2600 Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Vestergaard","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital, Department of Neurology, PJJ Boulevard 165, J504, 8200 Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke Marie","family":"Jensen","sequence":"additional","affiliation":[{"name":"Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet Glostrup, Valdemar Hansens Vej 13, 2600 Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke Marie","family":"Jensen","sequence":"additional","affiliation":[{"name":"Danish Multiple Sclerosis Center, Department of 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B. Winsl\u00f8ws Vej 4, 5000 Odense, Denmark, Department of Clinical Research, University of Southern Denmark, J. B. Winsl\u00f8ws Vej 4, 5000 Odense, Denmark. The Danish Multiple Sclerosis Registry, Department of Neurology, Copenhagen University Hospital\u2014Rigshospitalet, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"bibr1-13524585241299715","unstructured":"European Medicines Agency Aubagio. EPAR product information), https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/aubagio (2021, accessed 18 March 2024)."},{"key":"bibr2-13524585241299715","unstructured":"European Medicines Agency Tecfidera. 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