{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:37:48Z","timestamp":1777937868538,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Little is known about how multiple sclerosis (MS) presents in Hispanic\/Latinx (HL) people with MS (pwMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Compare age at onset (AAO) and onset severity between HL versus non-Hispanic White (NHW) pwMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A cross-sectional study leveraged the MS PATHS registry spanning seven US tertiary care institutions. HL was subcategorized as HL White (HLW) and HL Other (HLO; all other races). Multivariable models examined relationships between ethnoracial variables and AAO and self-reported presenting disease course. Models were repeated restricting to those born \u2a7e1970.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The study population included 8231 pwMS, including 540 HL (200 HLW, 340 HLO). The sex distribution did not differ across ethnoracial subgroups. From the statistical models (1) HLO pwMS had an earlier AAO and a higher prevalence of initial progressive disease course than NHW pwMS; (2) among all HL pwMS, irrespective of race, AAO did not differ by sex or between relapsing and progressive MS at onset. In younger HLO adults (born \u2a7e1970), those with progressive MS at onset had an earlier AAO than those with relapsing MS; and (3) in HL pwMS there was no sex-bias in presenting disease course.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Distinct differences in the presentation of MS in HL compared with NHW individuals were observed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585241304976","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T06:54:01Z","timestamp":1735023241000},"page":"197-206","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The onset presentation of multiple sclerosis differs in Hispanic\/Latinx Americans compared with non-Hispanic White Americans"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0903-1359","authenticated-orcid":false,"given":"Farren BS","family":"Briggs","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5359-6686","authenticated-orcid":false,"given":"Devon S","family":"Conway","sequence":"additional","affiliation":[{"name":"The Mellen Center for Multiple Sclerosis and Research, Department of Neurology, Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5716-5645","authenticated-orcid":false,"given":"Carrie M","family":"Hersh","sequence":"additional","affiliation":[{"name":"Lou Ruvo Center for Brain Health, Cleveland Clinic Foundation, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3137-0322","authenticated-orcid":false,"given":"Kathryn C","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0623-5188","authenticated-orcid":false,"given":"Ellen","family":"Mowry","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9245-9772","authenticated-orcid":false,"given":"Jeffrey A","family":"Cohen","sequence":"additional","affiliation":[{"name":"The Mellen Center for Multiple Sclerosis and Research, Department of Neurology, Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2838-9148","authenticated-orcid":false,"given":"Daniel","family":"Ontaneda","sequence":"additional","affiliation":[{"name":"The Mellen Center for Multiple Sclerosis and Research, Department of Neurology, Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"bibr1-13524585241304976","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.1135"},{"key":"bibr2-13524585241304976","unstructured":"United States Census Bureau. 2010 Census Shows America\u2019s Diversity 2011 [CB11-CN.125], https:\/\/www.census.gov\/newsroom\/releases\/archives\/2010_census\/cb11-cn125.html"},{"key":"bibr3-13524585241304976","unstructured":"United States Census Bureau. The Hispanic population in the United States: 2020, 2020, https:\/\/www.census.gov\/data\/tables\/2020\/demo\/hispanic-origin\/2020-cps.html"},{"key":"bibr4-13524585241304976","unstructured":"Zong J. A mosaic, not a monolith: A profile of the U.S. Latino population, 2000-2020. Latino Policy & Politics Institute, 2022, https:\/\/latino.ucla.edu\/research\/latino-population-2000-2020\/"},{"key":"bibr5-13524585241304976","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200151"},{"key":"bibr6-13524585241304976","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.104240"},{"key":"bibr7-13524585241304976","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.103784"},{"key":"bibr8-13524585241304976","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-020-01749-6"},{"key":"bibr9-13524585241304976","doi-asserted-by":"publisher","DOI":"10.1177\/2055217317725103"},{"key":"bibr10-13524585241304976","doi-asserted-by":"publisher","DOI":"10.1177\/1352458516679894"},{"issue":"4","key":"bibr11-13524585241304976","first-page":"451","volume":"20","author":"Buchanan RJ","year":"2010","journal-title":"Ethn Dis"},{"key":"bibr12-13524585241304976","unstructured":"Moslimni M, Hugo Lopez M, Noe-Bustamante L. 11 facts about Hispanic origin groups in the U.S. Pew Research Center, 2023, https:\/\/www.pewresearch.org\/short-reads\/2023\/08\/16\/11-facts-about-hispanic-origin-groups-in-the-us\/"},{"key":"bibr13-13524585241304976","unstructured":"United States Census Bureau. 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