{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:53:57Z","timestamp":1785426837913,"version":"3.56.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Exercise is a safe and effective way to improve physical function in people with multiple sclerosis (PWMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to perform a head-to-head study of the effects of aerobic and resistance training on physical capacity and physical function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A multicentre randomized controlled trial with 150 participants was conducted. Participants were randomized into 12\u2009weeks of either aerobic training (AT; n\u2009=\u200962), resistance training (RT; n\u2009=\u200957), or usual care (UC; n\u2009=\u200931). The primary outcome was physical function (measured as a composite score of the 6-minute walk test and five-time sit-to-stand). Secondary outcomes were aerobic capacity (VO\n                      <jats:sub>2<\/jats:sub>\n                      peak), maximal muscle strength (MVC), and self-reported walking ability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Participants had a mean age of 45.5 (8.8), an expanded disability status scale (EDSS) of 2.8 (1.5), and 75% were female. Physical function did not increase in AT versus UC 0.08 [\u22120.16; 0.33] (mean (95% CI)) nor in RT versus UC 0.09 [\u22120.15; 0.34].VO\n                      <jats:sub>2<\/jats:sub>\n                      peak increased in AT versus UC by 4.1 [2.0; 6.3]\u2009mL O\n                      <jats:sub>2<\/jats:sub>\n                      \/min\/kg and in AT versus RT by 2.7 [1.1; 4.3], but not in RT versus UC 1.4 [\u22120.6; 3.5]. MVC increased in RT versus UC by 0.25 [0.01; 0.48]\u2009Nm\/kg, but not in RT versus AT 0.17 [\u22120.02; 0.36] or AT versus UC 0.08 [\u22120.16; 0.31]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>AT and RT elicited improvements in physical capacity in PWMS. However, these improvements only moderately translated into improvements in physical function. Clinicaltrials.gov (NCT04913012) https:\/\/clinicaltrials.gov\/study\/NCT04913012<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585241305496","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T02:15:10Z","timestamp":1735611310000},"page":"174-183","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["A head-to-head comparison of the effects of aerobic versus resistance training on physical capacity and physical function in people with multiple sclerosis: Results from the MSBOOST trial"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8877-5967","authenticated-orcid":false,"given":"Laurits","family":"Taul-Madsen","sequence":"first","affiliation":[{"name":"Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3233-0429","authenticated-orcid":false,"given":"Lars G","family":"Hvid","sequence":"additional","affiliation":[{"name":"Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark; The Danish MS Hospitals, Ry and Haslev, Haslev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9519-4788","authenticated-orcid":false,"given":"Hjalte","family":"Riis","sequence":"additional","affiliation":[{"name":"Movement and Neuroscience, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus K","family":"Brol\u00f8s","sequence":"additional","affiliation":[{"name":"Movement and Neuroscience, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Lundbye-Jensen","sequence":"additional","affiliation":[{"name":"Movement and Neuroscience, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4132-2789","authenticated-orcid":false,"given":"Ulrik","family":"Dalgas","sequence":"additional","affiliation":[{"name":"Exercise Biology, Department of Public Health, Aarhus University, Aarhus, 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