{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:31:59Z","timestamp":1792740719250,"version":"4.5.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The clinical course of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is variable. However, robust markers of poor outcome and\/or relapse risk are still missing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the frequency of cerebrospinal fluid-restricted oligoclonal bands (CSF-OCB) in a national cohort of adult MOGAD patients and to assess their prognostic value for the risk of relapse and severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We included MOGAD adult patients fulfilling the MOGAD 2023 criteria who underwent CSF analysis at maximum 3 months from onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Data from 190 patients were collected. We found the presence of CSF-OCB in 32 patients (16.8%). Positive and negative CSF-OCB patients were similar for median age at onset, sex, clinical presentation, severity at onset, and residual disability. Relapses were more frequent in the CSF-OCB+ group (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.049), particularly within the first year of follow-up (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007). Although CSF-OCB+ was more frequently associated with imaging features suggestive of multiple sclerosis (MS) (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.014), 78% of these patients fulfilled the 2023 supportive features and 65% experienced lesion vanishing at follow-up magnetic resonance imaging (MRI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We found a higher risk of relapse in MOGAD with CSF-OCB particularly during the first year. Close attention is recommended regarding the risk of misdiagnosis with MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585241311435","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T07:13:17Z","timestamp":1736925197000},"page":"290-302","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of the predictive value of CSF-restricted oligoclonal bands on residual disability and risk of relapse in adult patients with MOGAD: MOGADOC study"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3507-5153","authenticated-orcid":false,"given":"Ryan","family":"Ramdani","sequence":"first","affiliation":[{"name":"Service de Neurologie, Scl\u00e9rose en Plaques, Pathologie de la My\u00e9line et Neuro-Inflammation, Hopital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Inflammatoires Rares du Cerveau et de la Moelle, Hopital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Pique","sequence":"additional","affiliation":[{"name":"Service de Neurologie, Scl\u00e9rose en Plaques, Pathologie de la My\u00e9line et Neuro-Inflammation, Hopital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Inflammatoires Rares du Cerveau et de la Moelle, Hopital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6291-8771","authenticated-orcid":false,"given":"Romain","family":"Deschamps","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Neurologie, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3386-6308","authenticated-orcid":false,"given":"Jonathan","family":"Ciron","sequence":"additional","affiliation":[{"name":"Department of Neurology, CRC-SEP, CHU de Toulouse, Toulouse, France INSERM UMR1291\u2014Universit\u00e9 Toulouse III, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7699-0328","authenticated-orcid":false,"given":"Elisabeth","family":"Maillart","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Neurologie, Centre de R\u00e9f\u00e9rence des Maladies Inflammatoires Rares du Cerveau et de la Moelle, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Audoin","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Marseille, Marseille, 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Ayrignac","sequence":"additional","affiliation":[{"name":"Service Scl\u00e9rose en Plaques et Substance Blanche, CHU de Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3683-5582","authenticated-orcid":false,"given":"Nicolas","family":"Collongues","sequence":"additional","affiliation":[{"name":"Service Maladie Inflammatoire du Syst\u00e8me Nerveux, CHU de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0020-8739","authenticated-orcid":false,"given":"Aur\u00e9lie","family":"Ruet","sequence":"additional","affiliation":[{"name":"Service de Neurologie Pathologies Inflammatoires du Syst\u00e8me Nerveux Central, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France"},{"name":"U1215 Neurocentre Magendie, Universit\u00e9 de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8671-7747","authenticated-orcid":false,"given":"Eric","family":"Thouvenot","sequence":"additional","affiliation":[{"name":"Service de Neurologie, CHU de N\u00eemes, N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Bourre","sequence":"additional","affiliation":[{"name":"Service de Neurologie, CHU de Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4074-6125","authenticated-orcid":false,"given":"Caroline","family":"Papeix","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Neurologie, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakhdar","family":"Benyahya","sequence":"additional","affiliation":[{"name":"Service de Neurologie, Scl\u00e9rose en Plaques, 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