{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:35Z","timestamp":1792800035755,"version":"4.5.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Roche","id":[{"id":"https:\/\/ror.org\/00by1q217","id-type":"ROR","asserted-by":"crossref"}]},{"name":"EDMUS Fundation"},{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ARSEP Fundation"},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Retrospective studies did not show strong evidence of higher risk of adverse neonatal or pregnancy outcomes in women with multiple sclerosis (MS) compared to general population, but there are contradictory data on prematurity, cesarean section, and small birthweight for gestational age (SGA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We compared pregnancy and birth outcomes in MS women included in RESPONSE, a French prospective cohort, with a recent survey (Enqu\u00eate Nationale P\u00e9rinatale (ENP)) describing leading indicators in perinatal epidemiology in France.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      On 7 April 2023, 476 pregnancies (461 MS women, 482 expected newborns) from RESPONSE were available. The ENP study reported 12,723 women and 12,939 expected newborns in March 2021. MS patients were older (mean age 32.6\u2009\u00b1\u20094.4 vs. 30.9\u2009\u00b1\u20095.3\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with similar rate of cesarean (23.8% vs. 21.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.115) and use of locoregional analgesia (86.6% vs. 85.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.51). Preterm birth was less frequent (4.0% vs. 7.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Birthweight of children from MS mothers was similar to general population (3240\u2009\u00b1\u2009477.2 vs. 3264.5\u2009\u00b1\u2009552.9\u2009g,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.22), with slightly more children with SGA (13.4% vs. 9.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This prospective and contemporary comparison of pregnancy in MS women and the French population provides reassuring results. In the future, we need to assess the impact of disease-modifying treatment exposure during conception.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585251316474","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T08:17:28Z","timestamp":1742285848000},"page":"324-337","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Pregnancy and birth outcomes in women with multiple sclerosis: Comparison of the RESPONSE study to the general French population"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7699-0328","authenticated-orcid":false,"given":"Elisabeth","family":"Maillart","sequence":"first","affiliation":[{"name":"Department of Neurology, AP-HP, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Multiple Sclerosis Center, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Rollot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Lyon, France; Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"Service de Neurologie, Scl\u00e9rose en plaques, Pathologies de la my\u00e9line et neuro-inflammation, Hospices Civils de Lyon, Bron, France"},{"name":"Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques, Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, Lyon, France"},{"name":"Eug\u00e8ne Devic EDMUS Foundation Against Multiple Sclerosis, Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8424-4499","authenticated-orcid":false,"given":"Emmanuelle","family":"Leray","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Rennes, EHESP, CNRS, Inserm, Ar\u00e8nes\u2014UMR 6051, RSMS (Recherche sur les Services et Management en Sant\u00e9)\u2014U 1309, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakhdar","family":"Benyahya","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Lyon, France; Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"Service de Neurologie, Scl\u00e9rose en plaques, Pathologies de la my\u00e9line et neuro-inflammation, Hospices Civils de Lyon, Bron, France"},{"name":"Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques, Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, Lyon, France"},{"name":"Eug\u00e8ne Devic EDMUS Foundation Against Multiple Sclerosis, Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Bourre","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHU Rouen, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarisse","family":"Carra-Dalli\u00e8re","sequence":"additional","affiliation":[{"name":"CRC SEP, CHU de Montpellier, INM, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5918-9261","authenticated-orcid":false,"given":"Romain","family":"Casey","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Lyon, France; Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"Service de Neurologie, Scl\u00e9rose en plaques, Pathologies de la my\u00e9line et neuro-inflammation, Hospices Civils de Lyon, Bron, France"},{"name":"Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques, Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, Lyon, France"},{"name":"Eug\u00e8ne Devic EDMUS Foundation Against Multiple Sclerosis, Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumaran","family":"Deiva","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires Paris Saclay, Site Bic\u00eatre, Service de Neurologie P\u00e9diatrique, CRMR Maladies Inflammatoires Rares du Cerveau et de la Moelle (MIRCEM), Le Kremlin-Bic\u00eatre, France"},{"name":"UMR 1184, le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Girod","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Lyon, France; Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"Service de Neurologie, Scl\u00e9rose en plaques, Pathologies de la my\u00e9line et neuro-inflammation, Hospices Civils de Lyon, Bron, France"},{"name":"Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques, Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, Lyon, France"},{"name":"Eug\u00e8ne Devic EDMUS Foundation Against Multiple Sclerosis, Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Guennoc","sequence":"additional","affiliation":[{"name":"Department of Neurology, CRC SEP, CHU Tours, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5967-2800","authenticated-orcid":false,"given":"Romain","family":"Marignier","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, H\u00f4pital Neurologique Pierre Wertheimer, Service de Neurologie, Scl\u00e9rose en Plaques, Pathologies de la My\u00e9line et Neuro Inflammation, Bron, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Inflammatoires Rares du Cerveau et de la Moelle (MIRCEM), H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Labauge","sequence":"additional","affiliation":[{"name":"CRC SEP, CHU de Montpellier, INM, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Bensa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rothschild Foundation Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"De S\u00e8ze","sequence":"additional","affiliation":[{"name":"Department of Neurology and CIC 1434, CHU de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHU de Besan\u00e7on, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0569-629X","authenticated-orcid":false,"given":"Damien","family":"Biotti","sequence":"additional","affiliation":[{"name":"Maladies inflammatoires SNC\u2014CHU PURPAN\u2014H\u00f4pital Pierre-Paul Riquet\u2014Place du Dr Baylac, Toulouse, France"},{"name":"INSERM UMR1291\u2014Universit\u00e9 Toulouse III, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Bresch","sequence":"additional","affiliation":[{"name":"CHU de Nice Pasteur 2, CRCSEP C\u00f4te d\u2019Azur, Nice, France"},{"name":"Universit\u00e9 Nice C\u00f4te d\u2019Azur UR2CA-URRIS, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8671-7747","authenticated-orcid":false,"given":"Eric","family":"Thouvenot","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nimes University Hospital, N\u00eemes, France"},{"name":"Institut de G\u00e9nomique Fonctionnelle, UMR5203, INSERM 1191, Univ. Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Moreau","sequence":"additional","affiliation":[{"name":"CHU Pellegrin Bordeaux, Service de Neurologie Pathologie inflammatoire du syst\u00e8me nerveux central, Bordeaux, France"},{"name":"Inserm U1215\u2014Neurocentre Magendie, Universit\u00e9 de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Derache","sequence":"additional","affiliation":[{"name":"CRCSEP Normandie, Caen, France; Normandie SEP, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Z\u00e9phir","sequence":"additional","affiliation":[{"name":"Univ Lille, Inserm U 1172, CHU de Lille, Centre de ressources et de comp\u00e9tences pour la Scl\u00e9rose en Plaques, Centre de Comp\u00e9tence Maladies Rares pour les Maladies Inflammatoires du Cerveau et de la Moelle, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Le Page","sequence":"additional","affiliation":[{"name":"Neurology Department, Clinical Neuroscience Centre, CIC_P1414 INSERM, Rennes University Hospital, Rennes University, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Clavelou","sequence":"additional","affiliation":[{"name":"Department of Neurology, and INSERM NeuroDol U1107, CRC SEP Auvergne, CHU Clermont-Ferrand, Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Casez","sequence":"additional","affiliation":[{"name":"Neurologie, Pathologies Inflammatoires du Syst\u00e8me Nerveux, CRCSEP Grenoble, CHU Grenoble Alpes, Grenoble, France"},{"name":"TIMC, T-RAIG (Translational Research in Autoimmunity and Inflammation Group), Universit\u00e9 Grenoble Alpes, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Laplaud","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, INSERM, CHU de Nantes, Center for Research in Transplantation and Translational Immunology, UMR 1064, CIC INSERM 1413, CRC-SEP, Service de Neurologie, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Kwiatkowski","sequence":"additional","affiliation":[{"name":"Department of Neurology, Lille Catholic Hospitals, Lille Catholic University, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Grosset-Janin","sequence":"additional","affiliation":[{"name":"Service de Neurologie 1 \/ UNV, Centre Hospitalier M\u00e9tropole Savoie, Chamb\u00e9ry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Pittion-Vouyovitch","sequence":"additional","affiliation":[{"name":"Department of Neurology, CRC SEP, Nancy University Hospital, Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0020-8739","authenticated-orcid":false,"given":"Aur\u00e9lie","family":"Ruet","sequence":"additional","affiliation":[{"name":"CHU Pellegrin Bordeaux, Service de Neurologie Pathologie inflammatoire du syst\u00e8me nerveux central, Bordeaux, France"},{"name":"Inserm U1215\u2014Neurocentre Magendie, Universit\u00e9 de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Dos Santos","sequence":"additional","affiliation":[{"name":"Service de Neurologie, CRC SEP, CHU de Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Robert-Varvat","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Saint-Etienne, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Morel","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Annecy-Genevois, Service de Neurologie, Epagny-Metz-Tessy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3713-2416","authenticated-orcid":false,"given":"Christine","family":"Lebrun-Frenay","sequence":"additional","affiliation":[{"name":"CHU de Nice Pasteur 2, CRCSEP C\u00f4te d\u2019Azur, Nice, France"},{"name":"Universit\u00e9 Nice C\u00f4te d\u2019Azur UR2CA-URRIS, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7337-7122","authenticated-orcid":false,"given":"Sandra","family":"Vukusic","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Lyon, France; Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"},{"name":"Service de Neurologie, Scl\u00e9rose en plaques, Pathologies de la my\u00e9line et neuro-inflammation, Hospices Civils de Lyon, Bron, France"},{"name":"Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques, Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, Lyon, France"},{"name":"Eug\u00e8ne Devic EDMUS Foundation Against Multiple Sclerosis, Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0757-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1286314"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwy197"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000001035"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000188898.02018.95"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.120502"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508101937"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2006.00616.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c3f27d"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585221129472"},{"key":"e_1_3_3_12_2","unstructured":"SPF. Enqu\u00eate nationale p\u00e9rinatale. Rapport 2021. Les naissances le suivi \u00e0 deux mois et les \u00e9tablissements https:\/\/www.santepubliquefrance.fr\/import\/enquete-nationale-perinatale.-rapport-2021.-les-naissances-le-suivi-a-deux-mois-et-les-etablissements (accessed 14 September 2023)."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585231223390"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgyn.2015.08.009"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgyn.2015.08.008"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201027"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200106"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807303390501"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520978218"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518763080"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2021.100834"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2022-330883"},{"key":"e_1_3_3_23_2","unstructured":"Joint statement by UNICEF Executive Director and WHO Director-General on the occasion of World Breastfeeding Week https:\/\/www.who.int\/news\/item\/01-08-2023-joint-statement-by-unicef-executive-director-catherine-russell-and-who-director-general-dr-tedros-adhanom-ghebreyesus-on-the-occasion-of-world-breastfeeding-week (accessed 12 march 2024)."},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00426-4"},{"key":"e_1_3_3_25_2","first-page":"161","volume-title":"Rapport de Surveillance de La Sant\u00e9 P\u00e9rinatale En France","author":"Gomes E","year":"2022","unstructured":"Gomes E, Menguy C, Cahour L. Rapport de Surveillance de La Sant\u00e9 P\u00e9rinatale En France. 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