{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:34:32Z","timestamp":1792787672661,"version":"4.5.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Research Foundation of Korea","award":["NRF-2018R1A5A2023127"],"award-info":[{"award-number":["NRF-2018R1A5A2023127"]}],"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Research on the optimal duration of immunosuppressive therapy (IST) and the outcome upon its discontinuation in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the outcomes following IST discontinuation in MOGAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This multicenter retrospective study collected data from 333 MOGAD patients in Korea. Among 273 patients who received IST, 41 who discontinued IST were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The median age at disease onset was 38.3 years (interquartile range (IQR), 27.6\u201353.1). Before IST withdrawal, 21 (51%) patients exhibited relapsing courses. Over a median follow-up of 23.5 months (IQR, 12.1\u201339.5) after discontinuation, 10 patients (24.4%) relapsed after a median of 8.2 months (IQR, 6.3\u201311.5). All relapses occurred in patients with a prior relapsing course (10\/21, 47.6%); none with prior monophasic courses relapsed. Among 21 prior relapsing patients, relapse after discontinuation group had a shorter IST duration than non-relapse group (median, 9.4 vs 50.9 months,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.036). None of the 41 patients had severe disability (Expanded Disability Status Scale (EDSS) score \u2a7e 4.0 or Visual Functional System score \u2a7e 5) at the last visit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>IST discontinuation did not necessarily lead to relapse and could be considered with an individualized approach based on factors such as disease course and IST duration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585251320046","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T02:32:58Z","timestamp":1745893978000},"page":"1102-1109","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Outcomes of immunosuppressive therapy discontinuation in patients with myelin oligodendrocyte glycoprotein antibody-associated disease"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5189-1323","authenticated-orcid":false,"given":"You-Ri","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjin","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sungkyunkwan University School of Medicine, Neuroscience Center, Samsung Medical Center, Seoul, Korea"},{"name":"Department of Neurology, Soonchunhyang University Seoul Hospital, College of Medicine, Soonchunhyang University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6428-061X","authenticated-orcid":false,"given":"Ki Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Korea"},{"name":"Department of Neurology, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Ho","family":"Choo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sungkyunkwan University School of Medicine, Neuroscience Center, Samsung Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woohee","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sooyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of 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