{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:12:18Z","timestamp":1787019138856,"version":"build-2736575974"},"reference-count":10,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T00:00:00Z","timestamp":1746316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T00:00:00Z","timestamp":1746316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2025,10]]},"abstract":"\n Background:<\/jats:title>\n The full range of side effects of disease-modifying treatment for multiple sclerosis (MS) remains to be determined. To date, four serious varicella zoster virus (VZV) infections have been reported in association with dimethyl fumarate (DMF).<\/jats:p>\n <\/jats:sec>\n \n Report:<\/jats:title>\n A 44-year-old man on DMF for relapsing remitting MS presented with monocular pain and visual impairment. Ophthalmological examination revealed panuveitis with arteritis, retinitis and vitritis. Vitreous PCR was positive for VZV confirming the clinical impression of acute retinal necrosis (ARN).<\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n ARN due to VZV may mimic optic neuritis in people on disease-modifying therapy for MS.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/13524585251326475","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T01:08:09Z","timestamp":1746407289000},"page":"1506-1508","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute retinal necrosis associated with dimethyl fumarate"],"prefix":"10.1177","volume":"31","author":[{"given":"Christopher","family":"Paisey","sequence":"first","affiliation":[{"name":"Southmead Hospital, North Bristol NHS Trust, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Curtin","sequence":"additional","affiliation":[{"name":"Bristol Eye Hospital, University Hospitals of Bristol and Weston NHS Foundation Trust, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J","family":"Epps","sequence":"additional","affiliation":[{"name":"Bristol Eye Hospital, University Hospitals of Bristol and Weston NHS Foundation Trust, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9851-4426","authenticated-orcid":false,"given":"Claire M","family":"Rice","sequence":"additional","affiliation":[{"name":"Southmead Hospital, North Bristol NHS Trust, Bristol, UK; Translational Health Sciences, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-44310-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2011.338"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.114884"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/82_2010_31"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000076"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000203"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001017"},{"issue":"2","key":"e_1_3_3_9_2","article-title":"Varicella-zoster reactivation in a non-immunized elderly multiple sclerosis patient while on delayed-release dimethyl fumarate with grade 2 lymphopenia and profoundly low CD4+ and CD8+ cell counts: A case report","volume":"14","author":"Daripa B","year":"2022","unstructured":"Daripa B, Lucchese S. Varicella-zoster reactivation in a non-immunized elderly multiple sclerosis patient while on delayed-release dimethyl fumarate with grade 2 lymphopenia and profoundly low CD4+ and CD8+ cell counts: A case report. Cureus 2022; 14(2): e22679.","journal-title":"Cureus"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585231189641"},{"key":"e_1_3_3_11_2","unstructured":"Alaghband P Downey L Arora S. An unusual case of acute retinal necrosis. Eye News September 2015 https:\/\/www.eyenews.uk.com\/education\/photoessay\/post\/an-unusual-case-of-acute-retinal-necrosis"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585251326475","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585251326475","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585251326475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:17:56Z","timestamp":1777695476000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585251326475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,4]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/13524585251326475"],"URL":"https:\/\/doi.org\/10.1177\/13524585251326475","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,4]]}}}