{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:39:31Z","timestamp":1777937971145,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Capitainer","award":["Provided consumables for dried blood spot sampling"],"award-info":[{"award-number":["Provided consumables for dried blood spot sampling"]}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/Y008057\/1 provides support for Stuart Moat."],"award-info":[{"award-number":["MR\/Y008057\/1 provides support for Stuart Moat."]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"LFB","award":["Immunology Grant to Emily Carne"],"award-info":[{"award-number":["Immunology Grant to Emily Carne"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>\n                    Anti-CD20 monoclonal antibodies are commonly used to manage neuroinflammatory diseases. The rate of B-cell re-emergence after dosing of ocrelizumab or rituximab varies considerably between individuals, but most people remain completely B-cell depleted at 6\u2009months. Tailoring the dosing according to B-cell re-emergence may improve the safety profile of anti-CD20s but poses logistical challenges such as the need for regular attendances for whole-blood sampling. Here we combined a quantitative dried blood spot sampling technique with a DNA methylation test, to provide a reliable means of remotely monitoring B-cell counts, with 100% sensitivity and specificity for reaching &gt;10\u2009\u00d7\u200910\n                    <jats:sup>6<\/jats:sup>\n                    \u2009cells\/L.\n                  <\/jats:p>","DOI":"10.1177\/13524585251330962","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T07:02:11Z","timestamp":1743490931000},"page":"1007-1010","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Home-sampling of B cells using quantitative dried blood spots to enable tailored therapeutic re-dosing of anti-CD20 therapies"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3760-6634","authenticated-orcid":false,"given":"Emma C","family":"Tallantyre","sequence":"first","affiliation":[{"name":"Division of Psychological Medicine and Clinical Neuroscience, Cardiff University, Cardiff, UK"},{"name":"Helen Durham Neuro-inflammatory Centre, University Hospital of Wales, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Jacob","sequence":"additional","affiliation":[{"name":"Immunodeficiency Centre for Wales, University Hospital of Wales, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Davies","sequence":"additional","affiliation":[{"name":"Helen Durham Neuro-inflammatory Centre, University Hospital of Wales, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Loveless","sequence":"additional","affiliation":[{"name":"Division of Psychological Medicine and Clinical Neuroscience, Cardiff University, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Carne","sequence":"additional","affiliation":[{"name":"Immunodeficiency Centre for Wales, University Hospital of Wales, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kath","family":"Bramhall","sequence":"additional","affiliation":[{"name":"Immunodeficiency Centre for Wales, University Hospital of Wales, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janika","family":"Schulze","sequence":"additional","affiliation":[{"name":"Epimune GmbH, Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart J","family":"Moat","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Immunology &amp; Toxicology, University Hospital Wales, Cardiff, UK"},{"name":"University Hospital Wales, School of Medicine, Cardiff University, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Jolles","sequence":"additional","affiliation":[{"name":"Immunodeficiency Centre for Wales, University Hospital of Wales, Cardiff, UK"},{"name":"University Hospital Wales, School of Medicine, Cardiff University, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-9092-4"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585211028833"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan3508"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103448"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005516"},{"key":"e_1_3_2_7_2","article-title":"Efficacy of rituximab outlasts B-cell repopulation in multiple sclerosis","volume":"10","author":"Claverie R","year":"2024","unstructured":"Claverie R, Perriguey M, Rico A, et al. Efficacy of rituximab outlasts B-cell repopulation in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 2024; 10: e200152.","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medj.2023.05.001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.105028"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167433"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-023-01464-0"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585251330962","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585251330962","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585251330962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:18:10Z","timestamp":1777695490000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585251330962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1177\/13524585251330962"],"URL":"https:\/\/doi.org\/10.1177\/13524585251330962","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]}}}