{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:27:49Z","timestamp":1791689269396,"version":"4.3.4"},"reference-count":60,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100017147","name":"International Progressive MS Alliance","doi-asserted-by":"publisher","award":["#PA-2304-41062"],"award-info":[{"award-number":["#PA-2304-41062"]}],"id":[{"id":"10.13039\/100017147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>Cognitive impairment (CI) is a common and disabling symptom in people with multiple sclerosis (PwMS), significantly affecting employment outcomes and quality of life. Despite its prevalence, routine assessment of CI is often hindered by limited access to comprehensive neuropsychological evaluations and challenges in interpreting subjective concerns. The relationship between objective and subjective measures of cognition is complex and often discordant. This review provides an overview focused on patient-reported CI, emphasizing on the association with objective measures of CI, the role of confounding factors, and the limitations of current screening approaches. Regardless of the underlying processes driving these concerns, patient-reported CI has a significant impact on day-to-day quality of life of PwMS and needs to be efficiently evaluated and addressed as several reversible causes can be managed efficiently when detected.<\/jats:p>","DOI":"10.1177\/13524585251334488","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T02:41:55Z","timestamp":1750819315000},"page":"896-904","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Addressing patient-reported cognitive impairment in multiple sclerosis clinical practice: A challenging endeavor"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7303-2332","authenticated-orcid":false,"given":"Gabrielle","family":"Macaron","sequence":"first","affiliation":[{"name":"Neurology Department, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada"},{"name":"Department of Neurosciences, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada"},{"name":"Neuroimmunology Research Department, Centre de Recherche, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour","family":"Farah","sequence":"additional","affiliation":[{"name":"Neuroimmunology Research Department, Centre de Recherche, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Charbonneau","sequence":"additional","affiliation":[{"name":"Psychology Department, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7522-6440","authenticated-orcid":false,"given":"Sarah A","family":"Morrow","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amel","family":"Zertal","sequence":"additional","affiliation":[{"name":"Neuroimmunology Research Department, Centre de Recherche, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave","family":"Saint-Amour","sequence":"additional","affiliation":[{"name":"Psychology Department, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7231-1754","authenticated-orcid":false,"given":"Pierre","family":"Duquette","sequence":"additional","affiliation":[{"name":"Neurology Department, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada"},{"name":"Department of Neurosciences, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada"},{"name":"Neuroimmunology Research Department, Centre de Recherche, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Rouleau","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada Neuroimmunology Research Department, Centre de Recherche, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"},{"name":"Psychology Department, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517694432"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458516633517"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.5.685"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30277-5"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585211002097"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519878685"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519898108"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.4920"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003236"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-016-9320-6"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518803785"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2020.97"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103106"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1191\/1352458503ms861oa"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458515599450"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2007.07.002"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2023.2213847"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14239"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617722000212"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-17649-3"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1191\/1352458504ms1098oa"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1101\/2024.04.29.24306587"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1017\/S031716710005410X"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1191\/1352458505ms1110oa"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/13803390701380617"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518769837"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14012"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2024.105645"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibneur.2022.10.016"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520922830"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/2055217319827618"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S199746"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.01.055.Hughes"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0019222.Relationship"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0016064"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617715000053"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dhjo.2019.06.003"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585221114004"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1515\/SJPAIN-2021-0067\/ASSET\/GRAPHIC\/J_SJPAIN-2021-0067_FIG_002.JPG"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.104584"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2009.07.005"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1177\/2055217315577828"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/S11910-018-0809-7"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1080\/15402002.2016.1173553"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1177\/15459683211046257"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.065805"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2017.06.017.Relationship"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103316"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.04.018"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnp.12197"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2020.1720646"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585221122207"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2014.02.013"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1682\/jrrd.2004.11.0148"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519860318"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000710"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.101479"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585241230184"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/S41582-022-00735-5"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.MSARD.2023.104916"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585251334488","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585251334488","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585251334488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:18:21Z","timestamp":1777695501000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585251334488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,18]]},"references-count":60,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1177\/13524585251334488"],"URL":"https:\/\/doi.org\/10.1177\/13524585251334488","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,18]]}}}