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This cross-sectional study examines the features of raised ICP in aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS). Lumbar puncture opening pressure (OP) done within 30 days of an attack was identified in 41 NMOSD patients and 37 MS patients. Raised OP was present in 7 (17.1%) NMOSD patients and 4 (10.8%) MS patients who were largely asymptomatic, partially explained by obesity, and did not require ICP lowering medications beyond acute treatment with corticosteroids.<\/jats:p>","DOI":"10.1177\/13524585251340841","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T04:21:11Z","timestamp":1748233271000},"page":"1247-1253","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of increased opening pressure in patients with multiple sclerosis and aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder"],"prefix":"10.1177","volume":"31","author":[{"given":"Sydney","family":"Roston","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie 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