{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:11:22Z","timestamp":1785265882519,"version":"3.55.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Clonus is a disabling symptom of upper motor neuron dysfunction in patients with multiple sclerosis (MS). We report immediate termination of mechanically evoked clonus by epidural lumbosacral spinal cord stimulation (ES) in a 58-year-old man with secondary progressive MS. This observation was captured during training using video and skin surface electromyography of soleus muscle activity. ES immediately reduced mechanically evoked clonus duration and cycle count compared to trials without stimulation, as determined by a Kruskal\u2013Wallis test (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.05,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 2\u20133 trials), and reverted to baseline status when stimulation was off.\n                  <\/jats:p>","DOI":"10.1177\/13524585251357143","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T14:26:51Z","timestamp":1753712811000},"page":"144-147","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Percutaneous epidural spinal cord stimulation immediately reduces clonus in an individual with multiple sclerosis"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7793-9951","authenticated-orcid":false,"given":"Anders J","family":"Asp","sequence":"first","affiliation":[{"name":"Assistive and Restorative Technology Laboratory, Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5379-1462","authenticated-orcid":false,"given":"Omid","family":"Jahanian","sequence":"additional","affiliation":[{"name":"Assistive and Restorative Technology Laboratory, Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan L","family":"Gill","sequence":"additional","affiliation":[{"name":"Assistive and Restorative Technology Laboratory, Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8250-3848","authenticated-orcid":false,"given":"Daniel D","family":"Veith","sequence":"additional","affiliation":[{"name":"Assistive and Restorative Technology Laboratory, Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3231-9003","authenticated-orcid":false,"given":"Katrina A","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA"},{"name":"Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8015-8660","authenticated-orcid":false,"given":"Candee J","family":"Mills","sequence":"additional","affiliation":[{"name":"Assistive and Restorative Technology Laboratory, Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R","family":"Thoreson","sequence":"additional","affiliation":[{"name":"Assistive and Restorative Technology Laboratory, Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol M","family":"Larson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"},{"name":"Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A","family":"Sagen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"},{"name":"Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Grahn","sequence":"additional","affiliation":[{"name":"Assistive and Restorative Technology Laboratory, Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, MN, USA"},{"name":"Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin D","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA"},{"name":"Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8141-2394","authenticated-orcid":false,"given":"W Oliver","family":"Tobin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"},{"name":"Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520929192"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009283431307"},{"key":"e_1_3_3_4_2","unstructured":"Emos MC Agarwal S. Neuroanatomy upper motor neuron lesion. Statpearls [Online]. Treasure Island FL: Statpearls Publishing 2024. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK537305\/ (accessed April 19 2024)."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevPhysRehabilMed.2013007945"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","unstructured":"Goodwin BJ Mahmud R TomThundyil S et al. The efficacy of spinal cord stimulators in the reduction of multiple sclerosis spasticity: A narrative systematic review. Brain Neurorehabil 2023; 16: e19. https:\/\/doi.org\/10.12786\/bn.2023.16.e19 (accessed April 9 2024).","DOI":"10.12786\/bn.2023.16.e19"},{"key":"e_1_3_3_7_2","first-page":"2868","article-title":"Chronic dorsal column stimulation in multiple sclerosis. Preliminary report","volume":"73","author":"Cook AW","year":"1973","unstructured":"Cook AW, Weinstein SP. Chronic dorsal column stimulation in multiple sclerosis. Preliminary report. N Y State J Med 1973; 73: 2868\u20132872.","journal-title":"N Y State J Med"},{"key":"e_1_3_3_8_2","first-page":"279175","article-title":"Clinical understanding of spasticity: Implications for practice","volume":"2014","author":"Bhimani R","year":"2014","unstructured":"Bhimani R, Anderson L. Clinical understanding of spasticity: Implications for practice. Rehabil Res Pract 2014; 2014: 279175.","journal-title":"Rehabil Res Pract"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510395056"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01196-1"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585221114438"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585251357143","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585251357143","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585251357143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:35:31Z","timestamp":1782963331000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585251357143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/13524585251357143"],"URL":"https:\/\/doi.org\/10.1177\/13524585251357143","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,28]]}}}