{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:14:47Z","timestamp":1793196887627,"version":"4.5.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100007217","name":"Health Services Research and Development","doi-asserted-by":"publisher","award":["I01CX002160-01A1"],"award-info":[{"award-number":["I01CX002160-01A1"]}],"id":[{"id":"10.13039\/100007217","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["RG-1901-33190"],"award-info":[{"award-number":["RG-1901-33190"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["RG-2111-38720"],"award-info":[{"award-number":["RG-2111-38720"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The selective inversion recovery quantitative magnetization transfer imaging-derived macromolecular-to-free pool size ratio (PSR) and the magnetization transfer imaging-derived magnetization transfer ratio (MTR) are both indirect indicators of myelin integrity. However, it remains unknown whether the two measures perform equally in clinical studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To compare the accuracy and effect size (ES) of PSR and MTR in assessing white matter (WM) injury in the brain of people with multiple sclerosis (PwMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>MTR and PSR were measured in lesions and normal-appearing white matter (NAWM) of 40 PwMS and in the normal white matter (NWM) of 16 healthy controls (HCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In total, 231 T\n                      <jats:sub>2<\/jats:sub>\n                      -lesions, 257 chronic black holes (cBHs), 450 regions of interest (ROIs) in NAWM proximal (pNAWM) and distant (dNAWM) to lesions of PwMS, and 150 NWM ROIs of HCs were assessed. PSR was more accurate (\n                      <jats:italic>p<\/jats:italic>\n                      \u2a7d 0.046) and had higher ES (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) than MTR in differentiating T\n                      <jats:sub>2<\/jats:sub>\n                      -lesions from pNAWM, dNAWM, or NWM. PSR was more accurate (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.006) than MTR in differentiating cBHs from NWM and showed higher ES (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003) when comparing cBHs with pNAWM and dNAWM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>PSR has greater accuracy and ES than MTR in distinguishing WM areas with different degrees of tissue injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585251364766","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T11:32:53Z","timestamp":1756726373000},"page":"1205-1217","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparing the macromolecular-to-free pool size ratio and the magnetization transfer ratio for the assessment of myelin injury in early multiple sclerosis"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4688-9728","authenticated-orcid":false,"given":"Ahmad A","family":"Toubasi","sequence":"first","affiliation":[{"name":"Neuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Graham","sequence":"additional","affiliation":[{"name":"Neuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Lake Erie College of Osteopathic Medicine, Bradenton, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8455-980X","authenticated-orcid":false,"given":"Gary","family":"Cutter","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health, The University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Gheen","sequence":"additional","affiliation":[{"name":"Neuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taegan","family":"Vinarsky","sequence":"additional","affiliation":[{"name":"Neuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Neuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Department of Computer Science, School of Engineering, Vanderbilt University, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Zhang","sequence":"additional","affiliation":[{"name":"Neuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"School of Science, Vanderbilt University, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Taylor","sequence":"additional","affiliation":[{"name":"Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E","family":"Eaton","sequence":"additional","affiliation":[{"name":"Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Cognitive Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D","family":"Dortch","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Departments of Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Sciences, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9544-9019","authenticated-orcid":false,"given":"Francesca","family":"Bagnato","sequence":"additional","affiliation":[{"name":"Neuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Department of Neurology, VA Medical Center, TN Valley Healthcare System, Nashville, TN, 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