{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T22:51:40Z","timestamp":1794091900457,"version":"4.8.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","award":["R01HS029501; PI: Aparasu"],"award-info":[{"award-number":["R01HS029501; PI: Aparasu"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>With advances in disease-modifying therapies (DMTs), patients with multiple sclerosis (MS) are living longer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study examined MS prevalence and DMT use among older adults 65\u2009years and above in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study analyzed 2011-2021 Medicare fee-for-service claims data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The prevalence rate of MS in older adults increased by 15.49%, from 210.55 (per 100,000) in 2011 to 243.17 in 2021. Women comprised 75% of the aging MS population, and 90% were White. Over half were prescribed DMTs, mainly interferon-beta and glatiramer acetate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The study found an increasing prevalence of MS among older adults in the United States over the past decade, with over half using DMTs. Our findings highlight the need for increasing geriatric care for MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585251368687","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T05:45:50Z","timestamp":1756878350000},"page":"1595-1599","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence of multiple sclerosis and disease-modifying therapy use in older adults in the United States, 2011\u20132021"],"prefix":"10.1177","volume":"31","author":[{"given":"Jieni","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Health Outcomes and Policy, University of Houston College of Pharmacy, Houston, TX, USA; Population Health Outcomes and Pharmacoepidemiology Education and Research (P-HOPER Center), University of Houston College of Pharmacy, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George J","family":"Hutton","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2310-901X","authenticated-orcid":false,"given":"Rajender R","family":"Aparasu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Health Outcomes and Policy, University of Houston College of Pharmacy, Houston, TX, USA; Population Health Outcomes and Pharmacoepidemiology Education and Research (P-HOPER Center), University of Houston College of Pharmacy, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31829a3388"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-017-0771-9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12286-4"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12384-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182684707"},{"key":"e_1_3_2_7_2","unstructured":"Services CfMM. CMS program statistics\u2014Medicare total enrollment. 2023. https:\/\/data.cms.gov\/summary-statistics-on-beneficiary-enrollment\/medicare-and-medicaid-reports\/cms-program-statistics-medicare-total-enrollment (accessed 8 November 2024)."},{"key":"e_1_3_2_8_2","unstructured":"Tomicki S Pyenson BS. Multiple sclerosis: New perspectives on the patient journey: 2019 Update. https:\/\/us.milliman.com\/en\/insight\/multiple-sclerosis-new-perspectives-on-the-patient-journey-2019-update"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007035"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1756286420969016"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585251368687","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585251368687","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585251368687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:19:24Z","timestamp":1777695564000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585251368687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,2]]},"references-count":10,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1177\/13524585251368687"],"URL":"https:\/\/doi.org\/10.1177\/13524585251368687","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,2]]}}}