{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:03:23Z","timestamp":1788476603797,"version":"build-2803163510"},"reference-count":17,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study aimed to test the association between cervical canal area (CCaA), a proxy for spinal cord reserve, measured at the first demyelinating event and disability accumulation in people with multiple sclerosis (pwMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Subjects with a clinically isolated syndrome (CIS) enrolled at Cemcat between January 2009 and December 2014 were included if they had a baseline brain three-dimensional T1-weighted image (3DT1WI), at least a 10-year clinical follow-up, and diagnosis of MS during follow-up. Clinical data were collected at the onset of CIS, and at 6\u2009months, 1\u2009year, 5\u2009years, 10\u2009years, and at the last follow-up visit. CCaA was measured on 3DT1WI using a validated segmentation pipeline at the C2\/C3 and C3\/C4 disc levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of the initial 121 pwMS, the final cohort comprised 81 pwMS with CCaA measures at C2\/C3 and 76 pwMS at C3\/C4. Linear mixed-effects models showed that while CCaA was not predictive of Expanded Disability Status Scale (EDSS) at disease onset, its influence on disability accumulation increased over time (C3\/C4: CCaA-Time interaction, \u03b2 = \u22120.023,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.034).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Larger spinal cord reserve at disease onset appeared to be associated with a slower rate of disability accumulation, supporting the concept of spinal cord reserve.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585251378995","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T14:19:48Z","timestamp":1759846788000},"page":"1483-1492","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Long-term impact of spinal cord reserve on disability accumulation in multiple sclerosis"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8173-1723","authenticated-orcid":false,"given":"Paola","family":"Ajdinaj","sequence":"first","affiliation":[{"name":"Multiple Sclerosis Centre of Catalonia (Cemcat), Neurology Department, Vall d\u2019Hebron University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain; Department of Neuroscience, Imaging and Clinical Sciences (DNISC), University \u2018G. D\u2019Annunzio\u2019, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0338-4797","authenticated-orcid":false,"given":"Neus","family":"Mongay-Ochoa","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Centre of Catalonia (Cemcat), Neurology Department, Vall d\u2019Hebron University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain; Imaging and Neurostimulation, Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Alberich","sequence":"additional","affiliation":[{"name":"Section of Neuroradiology, Department of Radiology (IDI), Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9999-5359","authenticated-orcid":false,"given":"Mar","family":"Tintore","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Centre of Catalonia (Cemcat), Neurology Department, Vall d\u2019Hebron University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain; Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Vic\/Manresa, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Montalban","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Centre of Catalonia (Cemcat), Neurology Department, Vall d\u2019Hebron University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain; Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Vic\/Manresa, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2132-6750","authenticated-orcid":false,"given":"\u00c0lex","family":"Rovira","sequence":"additional","affiliation":[{"name":"Section of Neuroradiology, Department of Radiology (IDI), Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7356-3769","authenticated-orcid":false,"given":"Deborah","family":"Pareto","sequence":"additional","affiliation":[{"name":"Section of Neuroradiology, Department of Radiology (IDI), Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1589-2254","authenticated-orcid":false,"given":"Jaume","family":"Sastre-Garriga","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Centre of Catalonia (Cemcat), Neurology Department, Vall d\u2019Hebron University Hospital, Universitat Autonoma de Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318296e98b"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2022-330613"},{"key":"e_1_3_2_4_2","article-title":"Association of the cervical canal area with disability and progression in people with multiple sclerosis","volume":"104","author":"Mongay-Ochoa N","year":"2024","unstructured":"Mongay-Ochoa N, Pareto D, Alberich M, et al Association of the cervical canal area with disability and progression in people with multiple sclerosis. 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