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We report the first case of a 22-year-old male successfully managed with cladribine monotherapy, achieving sustained clinical remission of both CD and MS over a four-year follow-up. Cladribine is an immune reconstitution therapy targeting T and B lymphocytes, with additional immunomodulatory effects that may benefit both conditions. This case highlights the potential of cladribine as a reliable treatment option in selected patients with concomitant CD and MS, warranting further investigation.<\/jats:p>","DOI":"10.1177\/13524585251390859","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T06:55:57Z","timestamp":1764572157000},"page":"762-765","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Cladribine monotherapy in a patient with coexisting Crohn\u2019s disease and multiple sclerosis"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5153-8367","authenticated-orcid":false,"given":"Sol\u00e8ne","family":"Dauby","sequence":"first","affiliation":[{"name":"GIGA\u2014CRC In vivo Imaging, University of Li\u00e8ge, Li\u00e8ge, Belgium; Department of Neurology, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Dive","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7965-4629","authenticated-orcid":false,"given":"Emilie","family":"Lommers","sequence":"additional","affiliation":[{"name":"GIGA\u2014CRC In vivo Imaging, University of Li\u00e8ge, Li\u00e8ge, Belgium; 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