{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:04:17Z","timestamp":1782965057581,"version":"3.54.5"},"reference-count":35,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Speech patterns in multiple sclerosis (MS) are poorly characterized. Software such as Dysarthria Analyzer (DA) performs a detailed speech analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of the study is (1) to explore speech features in patients with MS and (2) to investigate correlations between speech features and clinic-demographic characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients underwent clinical assessments (Expanded Disability Status Scale (EDSS) and Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS)) and speech evaluation using the DA. Each patient performed 6 vocal tasks: phonation A, phonation I, reading, monologue, fast syllables repetitions. The DA extracted 23 speech features as age-, gender-, and education-adjusted z-scores against healthy controls. A principal component analysis was conducted. Correlations between the components and clinic-demographic features were assessed through stepwise analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We enrolled 72 patients (50 females; mean age 48.1\u2009\u00b1\u200910.9\u2009years; median EDSS of 3 (1.5\u20136.5)). Principal component analysis (PCA) identified a 7-component model: Voice Intensity, Voice Intensity Variation, Motor Coordination, Speech Diadochokinesis, Speech Speed, Voice Strength, Speech Latency. Higher EDSS is associated with worse Voice Intensity Variation (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u2009\u20130.23;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.05), Speech Speed (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u2009\u20130.40;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001) and Speech Latency (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u2009\u20130.23;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.05). Progressive MS patients showed worse Voice Intensity Variation (coeff. = \u22121.20;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.002). Worse cognitive functioning correlated with worse Speech Speed (coeff. = \u22120.38;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Detailed speech analysis can reveal useful clinical information about physical and cognitive disability in MS possibly representing an additional tool to assess disability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585251400108","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T07:28:11Z","timestamp":1766215691000},"page":"134-143","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dysarthria assessment in multiple sclerosis patients"],"prefix":"10.1177","volume":"32","author":[{"given":"Davide","family":"Ranucci","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizia","family":"Falco","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0756-9877","authenticated-orcid":false,"given":"Valerio","family":"Nicolella","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica Anna","family":"Marra","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Caracciolo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Migliaccio","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Corsini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9042-9866","authenticated-orcid":false,"given":"Antonio","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4286-8732","authenticated-orcid":false,"given":"Alessia","family":"Castiello","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9429-2769","authenticated-orcid":false,"given":"Maria","family":"Petracca","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2613-3090","authenticated-orcid":false,"given":"Marcello","family":"Moccia","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, Naples, Italy; 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