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This retrospective cohort study assessed the prevalence of progression independent of relapse activity (PIRA) and relapse-associated worsening (RAW) in Korean patients with MOGAD from five referral centers. Among 205 patients, 116 with \u2a7e1\u2009year of follow-up and a minimum of 3 documented EDSS scores were eligible for inclusion. Over a mean follow-up of 62.2\u2009months, PIRA occurred in two patients (1.7%) and RAW in six patients (5.2%), highlighting that PIRA is a rare and atypical event in MOGAD.<\/jats:p>","DOI":"10.1177\/13524585251408654","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T01:15:15Z","timestamp":1768353315000},"page":"642-646","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Rarity of silent progression: PIRA and RAW in myelin oligodendrocyte glycoprotein antibody\u2013associated disease"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6428-061X","authenticated-orcid":false,"given":"Ki Hoon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, South 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