{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T19:40:27Z","timestamp":1783194027076,"version":"3.54.6"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>A 48-year-old woman was diagnosed with multiple sclerosis (MS) in 2019. She participated with blood and cerebrospinal fluid samples as a spinal anaesthesia surgery patient for a case\u2013control study on viruses and MS in 2003. The study had already demonstrated intrathecal antibody synthesis (ITS) to Epstein-Barr virus (EBV) but not against measles, rubella and varicella-zoster (MRZ) reaction viruses in this individual at the time of recruitment. A 2025 study review established that she was the only patient in her control subgroup who also developed MS. This case shows that a specific EBV-ITS may be an early indicator of a \u2018biologically isolated syndrome\u2019 in MS.<\/jats:p>","DOI":"10.1177\/13524585261427398","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T13:10:46Z","timestamp":1773753046000},"page":"444-447","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Intrathecal synthesis of Epstein-Barr virus antibodies 15 years before onset of multiple sclerosis"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8523-4495","authenticated-orcid":false,"given":"Manuel Miguel","family":"Guerrero-Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"PhD Program in Clinical Medicine and Public Health, University of Granada, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Serrano-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Anaesthesiology and Reanimation Service, Hospital Universitario Cl\u00ednico San Cecilio, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Foronda-Bengoa","sequence":"additional","affiliation":[{"name":"Neurology Service, Hospital Universitario de Ja\u00e9n, Ja\u00e9n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1843-9002","authenticated-orcid":false,"given":"Francisco Javier","family":"Barrero-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"PhD Program in Clinical Medicine and Public Health, University of Granada, Granada, Spain; Neurology Service, Hospital Universitario Cl\u00ednico San Cecilio, Granada, Spain; Department of Medicine, School of Medicine, University of Granada and Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0249-2291","authenticated-orcid":false,"given":"Antonio","family":"Sorl\u00f3zano-Puerto","sequence":"additional","affiliation":[{"name":"PhD Program in Clinical Medicine and Public Health, University of Granada, Granada Spain; Department of Microbiology, School of Medicine, University of Granada and Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj8222"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.587078"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000212313"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2024-335689"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/135245859800400304"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2024.106173"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2416097121"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.104007"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abo7799"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-024-01153-5"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585261427398","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585261427398","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585261427398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:20:40Z","timestamp":1777695640000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585261427398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1177\/13524585261427398"],"URL":"https:\/\/doi.org\/10.1177\/13524585261427398","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]}}}