{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:20:28Z","timestamp":1792653628854,"version":"4.5.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine predictive factors influencing visual acuity (VA) recovery, optical coherence tomography (OCT) metrics and visual field (VF) parameters in inaugural optic neuritis (ON) of Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this retrospective study, we collected orbital MRI, ophthalmological evaluations (VA, OCT, VF), and acute treatment data. MRI assessed enhancement intensity, longitudinal extent, anatomical involvement, optic perineuritis and optic nerve head edema. Ophthalmological parameters included VA, VF mean deviation (MD), peripapillary retinal nerve fiber layer (pRNFL) thickness and macular ganglion cell-inner plexiform layer (mGCIPL) volume. Prognostic factors were assessed using regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We included 78 patients with inaugural MOGAD-ON. Complete VA recovery (logMAR\u2009\u2a7d\u20090) was achieved in 69 patients (88.5%). In multivariate analysis, high-dose intravenous methylprednisolone treatment delay was the only significant prognostic factor for final VA (\u03b2\u2009=\u20090.36,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.002) and VF MD (\u03b2\u2009= \u22120.31,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.037). In multivariate analysis, worse nadir VA predicted thinner final pRNFL (\u03b2\u2009= \u22120.40,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.003), while both longer MRI optic nerve lesion length (\u03b2\u2009= \u22120.31,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.021) and poorer nadir VA (\u03b2\u2009= \u22120.45,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001) were significantly associated with reduced final mGCIPL volumes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We found distinct prognostic factors between visual impairment and structural damage in MOGAD-ON, underscoring the need for prompt diagnosis and acute treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585261428950","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T08:29:08Z","timestamp":1776241748000},"page":"487-496","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Early corticosteroids predict visual whereas MRI lesion extent predicts retinal atrophy outcomes in MOG antibody\u2013associated optic neuritis"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0827-2737","authenticated-orcid":false,"given":"Camille","family":"Princet","sequence":"first","affiliation":[{"name":"Department of Neurology, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Shor","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Public Hospitals of Paris, La Piti\u00e9 Salp\u00eatri\u00e8re, University Hospitals, Sorbonne University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Boudot de la Motte","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeline","family":"Chaugne","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Lamirel","sequence":"additional","affiliation":[{"name":"Department of Neuro-Ophthalmolology, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustin","family":"Lecler","sequence":"additional","affiliation":[{"name":"Department of Radiology, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0292-8905","authenticated-orcid":false,"given":"Catherine","family":"Vignal-Clermont","sequence":"additional","affiliation":[{"name":"Department of Neuro-Ophthalmolology, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Brochard","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Marignier","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Maladies Inflammatoires Rares du Cerveau et de la Moelle, H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France; Department of Neurology, Scl\u00e9rose en Plaques, Pathologies de la My\u00e9line et Neuro-inflammation, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Papeix","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6291-8771","authenticated-orcid":false,"given":"Romain","family":"Deschamps","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Fondation Adolphe de Rothschild, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00218-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00431-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14089"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2024.08.018"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.07.020"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.103525"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13641"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2022-330360"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000002002"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2023-333133"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2024.105518"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103222"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-023-10139-8"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514538110"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012125"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000572"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090060061023"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15420"},{"issue":"4","key":"e_1_3_2_20_2","article-title":"Structural and functional markers of optic nerve damage in myelin oligodendrocyte glycoprotein antibody-associated optic neuritis","volume":"7","author":"Barnes S","year":"2021","unstructured":"Barnes S, You Y, Shen T, et al. Structural and functional markers of optic nerve damage in myelin oligodendrocyte glycoprotein antibody-associated optic neuritis. 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