{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:39:37Z","timestamp":1777937977721,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100008361","name":"Scleroseforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008361","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Postpartum depression (PPD) is a common mental health concern, but its occurrence among mothers with multiple sclerosis (MS) is not well established. Understanding this risk is important for guiding perinatal care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To investigate the risk of treatment-requiring PPD among mothers with MS compared to mothers without MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a nationwide cohort study including all live births in Denmark from 1997 to 2023, using Danish national health registers. Treatment-requiring PPD was defined as redeemed prescriptions for antidepressants within 12\u2009months postpartum, identified in the Danish National Prescription Register. Logistic regression models estimated crude and adjusted odds ratios (aORs), adjusting for maternal age, parity, preterm birth, multifetal gestation, and antidepressant use within 6\u2009months before conception. Analyses were clustered by mother.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Within 12\u2009months postpartum, 236 of 2850 deliveries in women with MS (8.3%) and 58,778 of 1,532,959 deliveries of women without MS (3.8%) redeemed antidepressant prescriptions. Mothers with MS had higher odds of antidepressant use with aOR 1.9 (95% confidence interval (CI): 1.6\u20132.3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Mothers with MS have an elevated risk of treatment-requiring PPD. Enhanced monitoring and tailored mental health support during the perinatal period may be warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585261429255","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:44:51Z","timestamp":1775205891000},"page":"497-505","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment-requiring postpartum depression in mothers with multiple sclerosis: A nationwide cohort study"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4598-8679","authenticated-orcid":false,"given":"Mette Louise","family":"Andersen","sequence":"first","affiliation":[{"name":"Center for Clinical Epidemiology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, Research Unit of Clinical Epidemiology, University of Southern Denmark, Odense, Denmark; Department of Gynecology and Obstetrics, Esbjerg and Grindsted Hospital, Esbjerg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7046-2556","authenticated-orcid":false,"given":"Pavithra Laxsen","family":"Anru","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, Research Unit of Clinical Epidemiology, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5184-4311","authenticated-orcid":false,"given":"Erantis","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, Research Unit of Clinical Epidemiology, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7433-7656","authenticated-orcid":false,"given":"Line Riis","family":"J\u00f8lving","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, Research Unit of Clinical Epidemiology, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsebeth","family":"Stenager","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research, Mental Health Services, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4877-5193","authenticated-orcid":false,"given":"Egon","family":"Stenager","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research, University of Southern Denmark, Odense, Denmark; Multiple Sclerosis Clinic of Southern Jutland, South Jutland Hospital Aabenraa Campus, Aabenraa, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"McElrath","sequence":"additional","affiliation":[{"name":"Department of Maternal-Fetal Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA; Department of Epidemiology, T.H. Chan School of Public Health, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente Mertz","family":"N\u00f8rg\u00e5rd","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, Research Unit of Clinical Epidemiology, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.08.001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.22"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1675646"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v13.i4.149"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)30284-X"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-024-03956-w"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.4363"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458516631037"},{"key":"e_1_3_2_10_2","volume-title":"Postpartum Depression","author":"Carlson K","year":"2024","unstructured":"Carlson K, Mughal S, Azhar Y, et al. Postpartum Depression. Treasure Island, FL: StatPearls, 2024."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585211041108"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000210170"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"issue":"4","key":"e_1_3_2_14_2","first-page":"441","article-title":"The Danish Civil Registration System. A cohort of eight million persons","volume":"53","author":"Pedersen CB","year":"2006","unstructured":"Pedersen CB, G\u00f8tzsche H, M\u00f8ller JO, et al. The Danish Civil Registration System. A cohort of eight million persons. Dan Med Bull 2006; 53(4): 441\u2013449.","journal-title":"Dan Med Bull"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_3_2_16_2","first-page":"798","article-title":"Data resource profile: The Danish National Prescription Registry","volume":"46","author":"Pottegard A","year":"2017","unstructured":"Pottegard A, Schmidt SAJ, Wallach-Kildemoes H, et al. Data resource profile: The Danish National Prescription Registry. Int J Epidemiol 2017; 46: 798\u2013798.","journal-title":"Int J Epidemiol"},{"key":"e_1_3_2_17_2","article-title":"The Danish National Prescription Registry","volume":"39","author":"Kildemoes HW","year":"2011","unstructured":"Kildemoes HW, Sorensen HT, Hallas J. The Danish National Prescription Registry. Scand J Public Health 2011; 39: 3820110804\u201341.","journal-title":"Scand J Public Health"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0356-1"},{"key":"e_1_3_2_19_2","first-page":"320","article-title":"The Danish Medical Birth Registry","volume":"45","author":"Knudsen LB","year":"1998","unstructured":"Knudsen LB, Olsen J. The Danish Medical Birth Registry. Dan Med Bull 1998; 45: 320\u2013323.","journal-title":"Dan Med Bull"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(96)00018-2"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S156997"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2011.01558.x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-11-83"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13289"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70251-0"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.054635"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511417835"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002174"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.21834"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1159\/000289052"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2021.1955302"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2018.1549990"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585261429255","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585261429255","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585261429255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:20:43Z","timestamp":1777695643000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585261429255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1177\/13524585261429255"],"URL":"https:\/\/doi.org\/10.1177\/13524585261429255","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}