{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:29:59Z","timestamp":1785774599106,"version":"3.56.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the French Public Health Doctoral Network","award":["Mobility Grant"],"award-info":[{"award-number":["Mobility Grant"]}]},{"DOI":"10.13039\/100007379","name":"Fondation pour l\u2019Aide \u00e0 la Recherche sur la Scl\u00e9rose en Plaques","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007379","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ARSEPEDMUS Foundation"},{"DOI":"10.13039\/100020827","name":"Institut des Neurosciences Cliniques de Rennes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["RG5063A4\/1\/RFA210337392"],"award-info":[{"award-number":["RG5063A4\/1\/RFA210337392"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000261","name":"MS Canada","doi-asserted-by":"crossref","award":["EGID: P002\/903124"],"award-info":[{"award-number":["EGID: P002\/903124"]}],"id":[{"id":"10.13039\/501100000261","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Neurological care and disease-modifying therapies (DMTs) are central to multiple sclerosis (MS) management, but how comorbidities like cancer affect them remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We assessed the impact of cancer on MS-related healthcare and DMT use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This cohort study accessed population-based data from France (2009\u20132021) and British Columbia, Canada (1991\u20132020). Cases were individuals with MS diagnosed with an incident cancer. The 4-year study period encompassed the 2\u2009years before and after the cancer diagnosis. Each case was matched to two cancer-free individuals with MS (i.e. controls). Outcomes were neurologist visit rates, MS hospitalization rates, and percentage of DMT users. Mixed-effects models were used with a knot at cancer diagnosis. Incidence rate ratios (IRRs) were estimated pre- and post-cancer (cases vs. controls) and compared using a slope ratio (SR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In total, 6902 cases were matched to 13,804 controls. There was a negative effect of cancer on DMT use (SR\u2009=\u20090.36 [0.19\u20130.70]), especially among those on chemotherapy (SR\u2009=\u20090.24 [0.14\u20130.40]). Neurologist visit IRRs did not differ pre- and post-cancer (SR\u2009=\u20090.96 [0.91\u20131.005]). Similarly, MS hospitalization IRRs did not differ (SR\u2009=\u20091.06 [0.84\u20131.33]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Following cancer, DMT use declined sharply. However, there was no evidence of a strong impact of cancer on neurologist visits and MS hospitalizations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585261437966","type":"journal-article","created":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T16:02:43Z","timestamp":1775404963000},"page":"525-538","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of cancer on multiple sclerosis\u2013related healthcare and disease-modifying drug use: A multinational cohort study"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2702-3343","authenticated-orcid":false,"given":"Chloe","family":"Pierret","sequence":"first","affiliation":[{"name":"Ecole des Hautes Etudes en Sante Publique, CNRS, Inserm, ARENES UMR 6051, RSMS U 1309, Rennes University, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1016-0828","authenticated-orcid":false,"given":"Geraldine","family":"Androdias","sequence":"additional","affiliation":[{"name":"Service de Neurologie, Scl\u00e9rose en plaques, Pathologies de la My\u00e9line et Neuro-Inflammation, H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3713-2416","authenticated-orcid":false,"given":"Christine","family":"Lebrun-Frenay","sequence":"additional","affiliation":[{"name":"Nice Cote d\u2019Azur UR2CA-URRIS, CRCSEP Centre Hospitalier Universitaire de Nice, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7337-7122","authenticated-orcid":false,"given":"Sandra","family":"Vukusic","sequence":"additional","affiliation":[{"name":"Service de Neurologie, Scl\u00e9rose en plaques, Pathologies de la My\u00e9line et Neuro-Inflammation, H\u00f4pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, France; Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France; Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques, Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, Lyon, France; Eug\u00e8ne Devic EDMUS Foundation against Multiple Sclerosis, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Maumy","sequence":"additional","affiliation":[{"name":"Ecole des Hautes Etudes en Sante Publique, CNRS, Inserm, ARENES UMR 6051, RSMS U 1309, Rennes University, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8381-5253","authenticated-orcid":false,"given":"Huah Shin","family":"Ng","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia; SA Pharmacy, SA Health, Northern Adelaide Local Health Network, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine (Neurology) and the Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5804-2535","authenticated-orcid":false,"given":"Helen","family":"Tremlett","sequence":"additional","affiliation":[{"name":"Faculty of Medicine (Neurology) and the Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8424-4499","authenticated-orcid":false,"given":"Emmanuelle","family":"Leray","sequence":"additional","affiliation":[{"name":"Ecole des Hautes Etudes en Sante Publique, CNRS, Inserm, ARENES UMR 6051, RSMS U 1309, Rennes University, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-315238"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-315907"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200005"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2023.12.007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8513-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007035"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7842-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514564489"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.195776"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.08.005"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15226"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209885"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws148"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585231175975"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06142-4"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.06.014"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2016-001432"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002543"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.2920"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.101955"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1197195"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585241274523"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585231214171"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585231223880"},{"key":"e_1_3_3_26_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.respe.2017.05.004","article-title":"Value of a national administrative database to guide public decisions: From the syst\u00e8me national d\u2019information interr\u00e9gimes de l\u2019Assurance Maladie (SNIIRAM) to the syst\u00e8me national des donn\u00e9es de sant\u00e9 (SNDS) in France","volume":"65","author":"Tuppin P","year":"2017","unstructured":"Tuppin P, Rudant J, Constantinou P, et al. 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