{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:49:36Z","timestamp":1788824976942,"version":"build-2803163510"},"reference-count":18,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Octave Bioscience"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aims to evaluate the ability of a multi-protein biomarker score to characterize clinical stability in relapsing-remitting multiple sclerosis (RRMS) compared to that of single-protein markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Serum was collected from 62 out of 86 MOVING MS participants over 12\u2009months (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      <jats:sub>samples<\/jats:sub>\n                      \u2009=\u2009186). Multiple Sclerosis Disease Activity (DA) scores were calculated from 18 proteins, sex, and age. In a clinically stable subcohort, the DA score reliability was compared to single biomarkers, and the minimum detectable change at 95% confidence (MDC95) was estimated. An independent cohort (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      \u2009=\u2009128) was used to assess whether change in the DA score\u2009&gt;\u2009MDC95 was associated with odds of gadolinium-enhancing (Gd+) lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In 34 clinically stable MOVING MS participants, the DA score demonstrated directionally stronger test\u2013retest reliability (r\n                      <jats:sub>XX\u2032<\/jats:sub>\n                      =\u20090.92, 95% CI\u2009=\u2009[0.79, 0.97]) than NfL (r\n                      <jats:sub>XX\u2032<\/jats:sub>\n                      =\u20090.75, 95% CI\u2009=\u2009[0.47, 0.91]) and GFAP (r\n                      <jats:sub>XX\u2032<\/jats:sub>\n                      \u2009=\u20090.71, 95% CI\u2009=\u2009[0.46, 0.89]). The DA score MDC95 was 1.24 units (95% CI\u2009= [0.74, 1.73]). In the independent cohort, DA score increases that were greater\/less than the MDC95 were significantly associated with increased\/decreased odds of Gd+ lesions across the DA score range.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The DA score directionally outperformed NfL and GFAP in test\u2013retest reliability. The MDC95 of 1.24 units provides a threshold for interpreting DA score changes, supporting its use for monitoring disease activity in RRMS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585261439680","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:28:13Z","timestamp":1778113693000},"page":"711-721","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal short-term assessments of single- and multi-protein disease activity biomarkers to determine reliability and the minimum detectable change in people with clinically stable RRMS"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5555-4156","authenticated-orcid":false,"given":"Shannon","family":"McCurdy","sequence":"first","affiliation":[{"name":"Octave Bioscience Inc., Menlo Park, CA, 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of clinical research: Applications to practice, third edition","author":"Portney LG","year":"2015","unstructured":"Portney LG, Watkins MP. Foundations of clinical research: Applications to practice, third edition. Philadelphia, PA: F.A. Davis, 2015."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(89)90005-6"},{"key":"e_1_3_2_15_2","volume-title":"Improving patient outcomes through a comprehensive care management platform (MOVING MS)","author":"Miner A","year":"2020","unstructured":"Miner A, Becich M, Gehman V, et al. Improving patient outcomes through a comprehensive care management platform (MOVING MS). Basel: ACTRIMS-ECTRIMS, 2020."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48602-9"},{"key":"e_1_3_2_17_2","volume-title":"Introduction to measurement theory","author":"Allen M","year":"2001","unstructured":"Allen M, Yen W. Introduction to measurement theory. Long Grove, IL: Waveland Press Inc, 2001."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/NPT.0b013e318219308c"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/0013164416678980"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585261439680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585261439680","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585261439680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:55:24Z","timestamp":1781002524000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585261439680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,6]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1177\/13524585261439680"],"URL":"https:\/\/doi.org\/10.1177\/13524585261439680","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,6]]}}}