{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:48:16Z","timestamp":1782481696491,"version":"3.54.5"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Natalizumab (NTZ) effectively suppresses clinical and radiologic disease activity in paediatric patients with multiple sclerosis (MS), however, it is unclear whether serum neurofilament light chain (sNfL), a biomarker of neuronal injury, normalizes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate sNfL response to NTZ in the paediatric setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      sNfL was measured (single-molecule array) in 66 paediatric patients on NTZ for highly active MS in a single-centre between 2007 and 2023. sNfL levels were converted to age-adjusted\n                      <jats:italic toggle=\"yes\">z<\/jats:italic>\n                      -scores for longitudinal assessment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      sNfL declined significantly on NTZ, however, not all patients achieved normalized levels. Percentage of patients with sNfL\u2009&lt;\u200990th percentile of healthy aged-matched individuals increased from 6.8% initially to 50%, 65% and 75% within 12, 24 and 36 treatment-months, respectively. Higher on-treatment levels were associated with higher baseline levels (\n                      <jats:italic toggle=\"yes\">B<\/jats:italic>\n                      \u2009=\u2009\n                      <jats:italic toggle=\"yes\">0<\/jats:italic>\n                      .791,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and John Cunningham virus (JCV) seropositivity (\n                      <jats:italic toggle=\"yes\">B<\/jats:italic>\n                      \u2009=\u20090.286,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). sNfL\u2009&gt;\u200997th percentile at 12 treatment-months indicated greater likelihood of disease activity in following year.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>NTZ treatment resulted in a significant reduction in sNfL levels, correlating with its clinical efficacy in paediatric MS. However, higher baseline sNfL concentrations were associated with a prolonged time to normalization. In addition, JCV seropositivity was linked to elevated NfL levels during treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585261450816","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:39:54Z","timestamp":1782229194000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum neurofilament light chain in paediatric patients treated with natalizumab for highly active multiple sclerosis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6195-741X","authenticated-orcid":false,"given":"Brenda","family":"Huppke","sequence":"first","affiliation":[{"name":"Department of Neuropediatrics, Jena University Hospital, Jena, Germany"},{"name":"Division of Pediatric Neurology, Department of Pediatrics and Adolescent Medicine, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Reinert","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics and Adolescent Medicine, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiebke","family":"Stark","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics and Adolescent Medicine, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4108-7109","authenticated-orcid":false,"given":"Jutta","family":"G\u00e4rtner","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics and Adolescent Medicine, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"},{"name":"German Center for Child and Adolescent Health (DZKJ), Partner Site G\u00f6ttingen, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Huppke","sequence":"additional","affiliation":[{"name":"Department of Neuropediatrics, Jena University Hospital, Jena, Germany; Center for Rare Diseases, Jena University Hospital, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.505"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.135"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067597"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511430704"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06211-8"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.923"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/356063a0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107829"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0058-z"},{"issue":"2","key":"e_1_3_2_11_2","first-page":"126","article-title":"Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome","volume":"87","author":"Disanto G","year":"2016","unstructured":"Disanto G, Adiutori R, Dobson R, et al. 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Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology 1983; 33(11): 1444\u20131452.","DOI":"10.1212\/WNL.33.11.1444"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70021-3"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00210-7"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000749"},{"issue":"3","key":"e_1_3_2_23_2","article-title":"Glial fibrillary acidic protein and neurofilament light chain as biomarkers in pediatric multiple sclerosis","volume":"10","author":"Saucier L","year":"2024","unstructured":"Saucier L, Healy BC, Saxena S, et al. Glial fibrillary acidic protein and neurofilament light chain as biomarkers in pediatric multiple sclerosis. 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