{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T07:45:16Z","timestamp":1782632716006,"version":"3.54.5"},"reference-count":7,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To date, real-world applications of the 2024 McDonald criteria have been limited to non-Asian cohorts, with a lack of data from Asian populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives and Methods:<\/jats:title>\n                    <jats:p>We evaluate the 2024 and 2017 McDonald criteria at disease onset in a large multicenter Korean multiple sclerosis (MS) cohort to assess differences in criteria fulfillment and time to diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In 306 individuals with MS, we compared the 2024 and 2017 McDonald criteria at disease onset. Under the 2024 criteria, all participants fulfilled diagnostic criteria at initial evaluation, whereas 90.5% (277\/306) met the 2017 criteria. Among 22 participants with clinically isolated syndrome who fulfilled the 2024 criteria earlier than the 2017 criteria, the median time to diagnosis was reduced by 5\u2009months. This difference was primarily attributable to the inclusion of optic nerve involvement as an additional dissemination in space site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings suggest that the 2024 McDonald criteria facilitate earlier MS diagnosis in real-world practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585261462503","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T10:15:48Z","timestamp":1782382548000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Application of the 2024 and 2017 McDonald criteria at disease onset in a multicenter Korean MS cohort"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0288-771X","authenticated-orcid":false,"given":"Jae-Won","family":"Hyun","sequence":"first","affiliation":[{"name":"Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6428-061X","authenticated-orcid":false,"given":"Ki Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Young","family":"Shin","sequence":"additional","affiliation":[{"name":"Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Ri","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Republic of Korea; Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai-Seung","family":"Nam","sequence":"additional","affiliation":[{"name":"Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woojun","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0679-0918","authenticated-orcid":false,"given":"Su-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-8419","authenticated-orcid":false,"given":"Ho Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(25)00270-4"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-025-13395-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2025.106740"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000214688"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585261421816"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585251399102"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585261462503","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585261462503","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585261462503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T07:18:12Z","timestamp":1782631092000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585261462503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":7,"alternative-id":["10.1177\/13524585261462503"],"URL":"https:\/\/doi.org\/10.1177\/13524585261462503","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"article-number":"13524585261462503"}}