{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:21:40Z","timestamp":1788531700262,"version":"build-2803163510"},"reference-count":29,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100020827","name":"Institut des Neurosciences Cliniques de Rennes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020827","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondation EDMUS"},{"DOI":"10.13039\/100007379","name":"Fondation pour l\u2032Aide \u00e0 la Recherche sur la Scl\u00e9rose en Plaques","doi-asserted-by":"publisher","award":["EDMUS-ARSEP Grant"],"award-info":[{"award-number":["EDMUS-ARSEP Grant"]}],"id":[{"id":"10.13039\/100007379","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>People with multiple sclerosis (pwMS) have a lower reported risk of colorectal cancer, which may reflect reduced access to colorectal cancer screening (CCS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Compare CCS in pwMS and the general population and identify barriers and facilitators using mixed methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In 2022\u20132024, PwMS aged 50\u201374\u2009years and matched controls (3:1) were selected. Overall and age-stratified CCS coverage rates were computed. In pwMS, multivariable mixed-effects logistic models identified factors associated with CCS\u2009\u2a7e\u200980%. Semi-structured interviews were carried out with 20 pwMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The cohort included 63,509 pwMS and 190,527 controls (72.0% women, mean age 59.2\u2009years). Annual CCS coverage was 41.2% in pwMS and 42.4% in controls (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In pwMS, CCS was higher in the 50\u201354\u2009years (+1.5%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and lower in the \u2a7e65\u2009years group (\u22121.6% to \u22126.2%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Male sex (odds ratio\u2009=\u20090.90; 95% CI\u2009=\u2009[0.86\u20130.93]) and lower ecological socioeconomic status (0.81 [0.76\u20130.86]) were associated with lower CCS, while disease-modifying therapies (1.12 [1.08\u20131.16]) and high healthcare use with higher CCS. Qualitative barriers included motor or digestive MS symptoms and feelings of disgust. Facilitators included health system trust and prevention awareness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>CCS is lower among older pwMS and remains suboptimal in both pwMS and controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585261465197","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T10:34:33Z","timestamp":1786098873000},"page":"1069-1082","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Colorectal cancer screening in individuals with multiple sclerosis: A mixed-methods study"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2702-3343","authenticated-orcid":false,"given":"Chlo\u00e9","family":"Pierret","sequence":"first","affiliation":[{"name":"Rennes University, \u00c9cole des Hautes Etudes en Sante Publique, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romane","family":"Bouvier","sequence":"additional","affiliation":[{"name":"Rennes University, \u00c9cole des Hautes Etudes en Sante Publique, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Kerbrat","sequence":"additional","affiliation":[{"name":"DAMAD, Plouzan\u00e9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8424-4499","authenticated-orcid":false,"given":"Emmanuelle","family":"Leray","sequence":"additional","affiliation":[{"name":"Rennes University, \u00c9cole des Hautes Etudes en Sante Publique, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209885"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws148"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000345366.10455.62"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011219"},{"issue":"4","key":"e_1_3_3_7_2","article-title":"Incidence of malignancy in multiple sclerosis: A cohort study in the Danish multiple sclerosis registry","volume":"7","author":"Noorgaard M","year":"2021","unstructured":"Noorgaard M, Veres K, Sellebjerg FT, et al. Incidence of malignancy in multiple sclerosis: A cohort study in the Danish multiple sclerosis registry. Mult Scler J\u2013Exp Transl Clin 2021; 7(4): 20552173211053939.","journal-title":"Mult Scler J\u2013Exp Transl Clin"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.104417"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012634"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34944"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dhjo.2025.101851"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200163"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.70183"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.29034\/ijmra.v10n1a3"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1258\/jhsrp.2007.007074"},{"key":"e_1_3_3_16_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.respe.2017.05.004","article-title":"Value of a national administrative database to guide public decisions: From the syst\u00e8me national d\u2019information interr\u00e9gimes de l\u2019Assurance Maladie (SNIIRAM) to the syst\u00e8me national des donn\u00e9es de sant\u00e9 (SNDS) in France","volume":"65","author":"Tuppin P","year":"2017","unstructured":"Tuppin P, Rudant J, Constantinou P, et al. Value of a national administrative database to guide public decisions: From the syst\u00e8me national d\u2019information interr\u00e9gimes de l\u2019Assurance Maladie (SNIIRAM) to the syst\u00e8me national des donn\u00e9es de sant\u00e9 (SNDS) in France. Rev Epidemiol Sante Publique 2017; 65: S149\u2013S167.","journal-title":"Rev Epidemiol Sante Publique"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000213586"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585261437966"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2023.12.007"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-9-33"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000471"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/0969141316630766"},{"key":"e_1_3_3_23_2","unstructured":"Huma\u2014Num. Documentation de l\u2019IR* Huma\u2014Num [Page Web]. 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