{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T08:25:17Z","timestamp":1786868717380,"version":"build-2736575974"},"reference-count":38,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To assess vaccine effectiveness (VE) of the recombinant zoster vaccine (RZV) in adults with multiple sclerosis (MS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective study included adults\u2009aged \u2a7e18\u2009years with MS insured by Medicare or one of seven United States (US) commercial health insurers from January 2018 to September 2023. Adults receiving two RZV doses\u2009\u2a7e28\u2009days apart were matched with\u2009four or less unvaccinated comparators on insurer, sex, and age. Adjusted hazard ratios (HRs) of incident herpes zoster (HZ)\u2009\u2a7e\u200931\u2009days after the second RZV dose were estimated using Cox models with inverse probability of treatment weighting applied to the matched cohorts to balance potential confounders. VE was calculated as (1\u2009\u2212\u2009HR)\u2009\u00d7\u2009100.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The Medicare cohort included 8705 vaccinated and 34,407 unvaccinated patients; the commercially insured cohort included 6025 vaccinated and 22,685 unvaccinated patients. Most patients in both cohorts were\u2009aged \u2a7e50\u2009years. Crude HZ incidence in unvaccinated patients was 13.7 and 12.7\/1000 person-years in the Medicare and commercially insured cohorts, while crude incidence among vaccinated patients was 4.6 and 2.4\/1000 person-years. Weighted analyses demonstrated VE of 64% (95% confidence interval [CI]: 51%\u201374%) in Medicare and 81% (95% CI: 70%\u201388%) in commercially insured patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>RZV demonstrated robust VE, preventing 64%\u201381% of HZ cases in this MS population predominantly aged 50 years or older.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585261468620","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T07:42:13Z","timestamp":1786606933000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of the recombinant zoster vaccine in adult patients with multiple sclerosis: A claims-based retrospective cohort study in the United States"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2846-7879","authenticated-orcid":false,"given":"Sheryl A","family":"Kluberg","sequence":"first","affiliation":[{"name":"Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie E","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O\u2019Mareen","family":"Spence","sequence":"additional","affiliation":[{"name":"GSK, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Driss","family":"Oraichi","sequence":"additional","affiliation":[{"name":"GSK, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Seifert","sequence":"additional","affiliation":[{"name":"GSK, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Ali","sequence":"additional","affiliation":[{"name":"GSK, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifeng","family":"Yun","sequence":"additional","affiliation":[{"name":"GSK, Rockville, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenice S","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Hugh","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meg","family":"Her","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Shattuck","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-8833","authenticated-orcid":false,"given":"Aziza","family":"Jamal-Allial","sequence":"additional","affiliation":[{"name":"Carelon Research, Wilmington, DE, USA; Fakeeh Care Group, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djeneba Audrey","family":"Djibo","sequence":"additional","affiliation":[{"name":"CVS Health, Blue Bell, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Daniels","sequence":"additional","affiliation":[{"name":"Carelon Research, Wilmington, DE, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianli","family":"Ma","sequence":"additional","affiliation":[{"name":"Humana Healthcare Research, Inc., Louisville, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl N","family":"McMahill-Walraven","sequence":"additional","affiliation":[{"name":"CVS Health, Blue Bell, PA, USA; Glade Oak, Inc., Royersford, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel P","family":"Ogilvie","sequence":"additional","affiliation":[{"name":"Optum, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Palmsten","sequence":"additional","affiliation":[{"name":"HealthPartners Institute, Bloomington, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mano","family":"Selvan","sequence":"additional","affiliation":[{"name":"Humana Healthcare Research, Inc., Louisville, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najat J","family":"Ziyadeh","sequence":"additional","affiliation":[{"name":"Optum, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamik","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Mass General Brigham, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Ogdie","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"George","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Centers for Disease Control and Prevention. 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