{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:26:45Z","timestamp":1787300805539,"version":"build-2736575974"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Innovative Health Initiative Joint Undertaking","award":["101112153"],"award-info":[{"award-number":["101112153"]}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictvi Ceske Republiky","doi-asserted-by":"publisher","award":["MH CZDRO-VFN64165"],"award-info":[{"award-number":["MH CZDRO-VFN64165"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo Skolstvi, Mladeze a Telovychovy","doi-asserted-by":"publisher","award":["LL2504"],"award-info":[{"award-number":["LL2504"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The utility of high-level linguistic analysis for longitudinal monitoring of multiple sclerosis (MS) and its relationship with progressive brain volume loss remains largely unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To characterize longitudinal changes in lexical and syntactic features in MS and determine whether linguistic alterations are associated with subsequent brain volume loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Ninety-seven patients with MS and 80 age- and sex-matched healthy controls completed story narration tasks at baseline and 2-year follow-up. Recordings were automatically transcribed and analyzed to extract five linguistic features. Magnetic resonance imaging (MRI) assessments were performed between the 2- and 7-year follow-ups. Linear mixed-effects models assessed linguistic decline over 2\u2009years and whether these early changes were associated with a subsequent 5-year brain volume loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Over 2\u2009years, patients with MS showed changes in vocabulary range (\u03b2\u2009=\u20090.53,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.008,\n                      <jats:italic toggle=\"yes\">q<\/jats:italic>\n                      \u2009=\u20090.02) and phrase repetition (\u03b2\u2009=\u20090.56,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.007,\n                      <jats:italic toggle=\"yes\">q<\/jats:italic>\n                      \u2009=\u20090.02). Early changes in these lexical features were associated with subsequent 5-year decline in total gray matter volume. Linguistic changes were also related to cortical gray matter and cerebellar volume loss but not to hippocampal or white matter volume loss.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Automated speech analysis captures progressive linguistic decline in MS. Early linguistic changes were associated with subsequent brain volume loss, supporting speech-derived biomarkers of neurodegeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585261477213","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:46:26Z","timestamp":1787028386000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Automated speech analysis reveals progressive linguistic changes associated with subsequent gray matter loss in multiple sclerosis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4710-8564","authenticated-orcid":false,"given":"Martin","family":"\u0160ubert","sequence":"first","affiliation":[{"name":"Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza","family":"Tykalov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Novotn\u00fd","sequence":"additional","affiliation":[{"name":"Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbora","family":"Srpov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Mot\u00fdl","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kr\u00e1sensk\u00fd","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat\u011bj","family":"Kudrna","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Van\u011b\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1915-0036","authenticated-orcid":false,"given":"Dana","family":"Hor\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3160-9022","authenticated-orcid":false,"given":"Tom\u00e1\u0161","family":"Uher","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1036-3054","authenticated-orcid":false,"given":"Jan","family":"Rusz","sequence":"additional","affiliation":[{"name":"Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic; Department of Neurology, Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.11.002"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11030464"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-025-03015-w"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.101896"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2016.09.005"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/02687038.2022.2099527"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/17562864231180719"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2025.106849"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2025.111251"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcae177"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2019.04.009"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.10.032"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-0314-x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-023-03189-8"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.5.871"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/13651501.2020.1775854"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520460115022"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/09296171003643098"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2024.105891"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585251398451"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awag107"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf446"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.10.002"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhac350"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2024.103609"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2021.682199"},{"issue":"3","key":"e_1_3_2_31_2","first-page":"386","article-title":"Consensus paper: Language and the cerebellum: An ongoing enigma","volume":"13","author":"Mari\u00ebn P","year":"2014","unstructured":"Mari\u00ebn P, Ackermann H, Adamaszek M, et al. Consensus paper: Language and the cerebellum: An ongoing enigma. Cerebellum 2014; 13(3): 386\u2013410.","journal-title":"Cerebellum"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11021-1"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508100505"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.11.018"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.78140"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585261477213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585261477213","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585261477213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:12:57Z","timestamp":1787299977000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585261477213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":34,"alternative-id":["10.1177\/13524585261477213"],"URL":"https:\/\/doi.org\/10.1177\/13524585261477213","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]},"article-number":"13524585261477213"}}