{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:46:36Z","timestamp":1791801996629,"version":"4.3.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS109023"],"award-info":[{"award-number":["R01NS109023"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The concept of affective reserve has been proposed, but not operationalized, as a buffer designed to regulate mood and behavior in response to adverse events. This study derived a residual-based metric of affective reserve and evaluated whether it mediated associations between having multiple sclerosis and subjective well-being in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Sociodemographics and brain pathology metrics were regressed against a composite mood, extraversion, and consciousness variable to derive affective reserve in a sample of older adults with multiple sclerosis (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009107) and without (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009104). Linear regressions were run to examine the associations between affective reserve and well-being, measured with the Short Form-12 Mental Composite Summary and Physical Composite Summary. Hayes\u2019 PROCESS was used to evaluate affective reserve as a mediator between group status and well-being.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Affective reserve was positively associated with both Mental Composite Summary and Physical Composite Summary. After covariate adjustments, affective reserve fully mediated the relationship between having multiple sclerosis and Mental Composite Summary (\n                      <jats:italic toggle=\"yes\">b<\/jats:italic>\n                      \u2009=\u20091.350, 95% confidence interval: 0.142\u20132.591) and partially mediated the association between multiple sclerosis and Physical Composite Summary (\n                      <jats:italic toggle=\"yes\">b<\/jats:italic>\n                      \u2009=\u20090.915, 95% confidence interval: 0.073\u20131.906).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This residual-based metric offers a novel approach for measuring affective reserve. Not only is it associated with both physical and mental well-being, but it explained the relationship between the latter and the presence of multiple sclerosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13524585261480508","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:53:08Z","timestamp":1787939588000},"page":"1214-1222","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Affective reserve in older adults with and without multiple sclerosis: A residual-based approach"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6928-3596","authenticated-orcid":false,"given":"Elizabeth S.","family":"Gromisch","sequence":"first","affiliation":[{"name":"Mandell Center for Multiple Sclerosis, Mount Sinai Rehabilitation Hospital, Trinity Health Of New England, Hartford, CT, USA"},{"name":"Department of Rehabilitative Medicine, Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, CT, USA"},{"name":"Department of Medical Sciences, Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, CT, USA"},{"name":"Department of Neurology, University of Connecticut School of Medicine, Farmington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1529-8842","authenticated-orcid":false,"given":"Frederick W.","family":"Foley","sequence":"additional","affiliation":[{"name":"Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA"},{"name":"Holy Name Medical Center Multiple Sclerosis Center, Teaneck, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2258-6933","authenticated-orcid":false,"given":"Mark E.","family":"Wagshul","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6639-0724","authenticated-orcid":false,"given":"Roee","family":"Holtzer","sequence":"additional","affiliation":[{"name":"Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA"},{"name":"Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.7224\/1537-2073.2018-087"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-14-128"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-315367"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/13524585251383381"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmen.0000083"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-11656-8"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8104-5"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.07.219"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-023-01054-3"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.7.823"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3758\/BRM.41.4.1149"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.2.251"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/135245859900500508"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458507078388"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-13-37"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-52001-2.00017-0"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2021.0414"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04951-z"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.032"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.021"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2006.00888.x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jrp.2017.02.004"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102560"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10245932"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2021.05.012"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.103752"},{"key":"e_1_3_3_30_2","volume-title":"SF-12: how to score the SF-12 physical and mental health summary scales","author":"Ware J","year":"1995","unstructured":"Ware J, Kosinski M, Keller S. 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