{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:54:34Z","timestamp":1790927674989,"version":"4.1.0"},"reference-count":9,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF 2011-02349698"],"award-info":[{"award-number":["RF 2011-02349698"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mult Scler"],"abstract":"<jats:p>Optic neuritis, a common manifestation of multiple sclerosis, involves acute axonal injury and variable visual recovery. We evaluated whether serum neurofilament light chain predicts visual and structural outcomes after first-episode optic neuritis. Fifty-one patients (mean age\u2009=\u200933\u2009years, 71% women) were followed for 24\u2009\u00b1\u20096\u2009months with low-contrast letter acuity testing and optical coherence tomography. Adjusting for age and sex, higher baseline serum neurofilament light chain predicted greater inter-eye differences in retinal nerve fibre layer (\u22124.65 \u00b5m per SD, p\u2009=\u20090.02), ganglion cell\/inner plexiform layer (\u22121.39 \u00b5m, p\u2009=\u20090.02) and 2.5% low-contrast letter acuity (\u22120.73, p\u2009=\u20090.05), but not high-contrast acuity. Early serum neurofilament light chain may stratify optic neuritis severity and guide neuroprotective trial selection.<\/jats:p>","DOI":"10.1177\/13524585261489992","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T10:46:10Z","timestamp":1790592370000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum NfL predicts visual recovery and neuronal loss after optic neuritis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8761-9337","authenticated-orcid":false,"given":"Gloria","family":"Dalla Costa","sequence":"first","affiliation":[{"name":"Harvard School of Public Health, Harvard University, Boston, MA, USA"},{"name":"San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pisa","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, UK"},{"name":"Experimental Neurophysiology Unit, Institute of Experimental Neuroscience, San Raffaele Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7376-9425","authenticated-orcid":false,"given":"Roberto","family":"Furlan","sequence":"additional","affiliation":[{"name":"Neuroimmunology Research Unit, Raffaele Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6989-1054","authenticated-orcid":false,"given":"Giancarlo","family":"Comi","sequence":"additional","affiliation":[{"name":"San Raffaele University, Milan, Italy"},{"name":"Centro Sclerosi Multipla Casa di Cura Igea, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9326-6753","authenticated-orcid":false,"given":"Letizia","family":"Leocani","sequence":"additional","affiliation":[{"name":"San Raffaele University, Milan, Italy"},{"name":"Experimental Neurophysiology Unit, Institute of Experimental Neuroscience, San Raffaele Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11919-2"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.017236"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0058-z"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006902"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa458"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458515599074"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-32748-5"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/01658107.2022.2025852"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14591"}],"container-title":["Multiple Sclerosis Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585261489992","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13524585261489992","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13524585261489992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:18:56Z","timestamp":1790925536000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13524585261489992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":9,"alternative-id":["10.1177\/13524585261489992"],"URL":"https:\/\/doi.org\/10.1177\/13524585261489992","relation":{},"ISSN":["1352-4585","1477-0970"],"issn-type":[{"value":"1352-4585","type":"print"},{"value":"1477-0970","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"article-number":"13524585261489992"}}