{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:23:03Z","timestamp":1785198183428,"version":"3.55.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1995,6,1]],"date-time":"1995-06-01T00:00:00Z","timestamp":801964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:p>An association between infectious mononucleosis (IM) and MS has been proposed. In a historical prospective study we used records from the Danish State Serum Institute on heterophils antibody (HA) tests for IM performed in all Danish patients over a number of years. Included in the analysis were 6853 HA-positive persons analyzed from 1968 to 1978 (except 1975) and 12 886 HA-negative per sons analyzed in the years 1968, 1969, 1970 and 1978. A search for these persons in the central nationwide Danish Multiple Sclerosis Registry (DMSR) was performed. Among the HA-positive persons 16 cases of MS which met the diagnostic criteria were found with onset of MS after the year of the HA test and before follow-up on 1 January 1991. The expected number for a Danish population, matched by sex, age and year at start of observation, was 5.70 (P&lt;0.05), the risk ratio being 2.81. No patient had developed MS before contracting IM. Among the HA-negative persons 12 were registered with onset of MS after the year of the HA test and before follow-up, the expected number being 10.47 (P &gt; 0.05). Although Epstein-Barr virus is not suggested in itself to be the cause of MS, we propose that it is a co-factor in the pathogenesis of this disease.<\/jats:p>","DOI":"10.1177\/135245859500100203","type":"journal-article","created":{"date-parts":[[2017,7,9]],"date-time":"2017-07-09T06:36:04Z","timestamp":1499582164000},"page":"73-77","source":"Crossref","is-referenced-by-count":71,"title":["Increased risk of multiple sclerosis after late Epstein-Barr virus infection: a historical prospective study"],"prefix":"10.1177","volume":"1","author":[{"given":"S","family":"Haahr","sequence":"first","affiliation":[{"name":"The Institute of Medical Microbiology, University of Aarhus, DK-8000 Aarhus C"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Koch-Henriksen","sequence":"additional","affiliation":[{"name":"The Danish Multiple Sclerosis Registry, Rigshospitalet, DK-2200 Copenhagen, Department of Neurology, Aalborg Hospital, DK-9000 Aalborg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"M\u00f8ller-Larsen","sequence":"additional","affiliation":[{"name":"The Institute of Medical Microbiology, University of Aarhus, DK-8000 Aarhus C"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LS","family":"Eriksen","sequence":"additional","affiliation":[{"name":"The Danish Institute for Clinical Epidemiology, DK-2100 Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HMK","family":"Andersen","sequence":"additional","affiliation":[{"name":"The Institute of Medical Microbiology, University of Aarhus, DK-8000 Aarhus C"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1995,6,1]]},"reference":[{"key":"atypb1","first-page":"3","volume-title":"McAlpine's Multiple Sclerosis.","author":"Martyn C","year":"1991","edition":"2"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.5.672"},{"key":"atypb3","first-page":"239","volume":"145","author":"Ambinder RF","year":"1994","journal-title":"Am J Pathol"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-0705-1_10"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1980.00500510052009"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.3.435"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410170412"},{"key":"atypb8","first-page":"55","volume":"1","author":"Myrmel H","year":"1992","journal-title":"NIPS Annals"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.6.825"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.2.167"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1159\/000110248"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-193201000-00010"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1988.tb03672.x"},{"key":"atypb14","first-page":"5","volume":"23","author":"Allison RS","year":"1954","journal-title":"Ulster Med J"},{"key":"atypb15","first-page":"182","volume":"47","author":"Hallee TJ","year":"1974","journal-title":"Yale J. 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