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To help clarify this question, we analyzed the first hypervariable D-loop sequences of the mtDNA in a group of randomly selected Caucasian MS patients, in MS patients with prominent optic neuritis (PON) and in controls. Phylogenetic analysis of these D-loop sequences revealed that individuals in both groups of patients are generally scattered in the Caucasian phylogeny. However, a small cluster of unrelated MS patients identified by this analysis suggests that a maternal lineage with MS relevant mtDNA sequences may exist, and merits a more comprehensive study.<\/jats:p>","DOI":"10.1177\/135245859600100505","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T08:04:46Z","timestamp":1499414686000},"page":"288-295","source":"Crossref","is-referenced-by-count":3,"title":["The evolutionary relationship among Caucasian MS patients and controls"],"prefix":"10.1177","volume":"1","author":[{"given":"B","family":"Kalman","sequence":"first","affiliation":[{"name":"Department of Neurology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Alder","sequence":"additional","affiliation":[{"name":"Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"UF","family":"Bosch","sequence":"additional","affiliation":[{"name":"Department of Neurology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FD","family":"Lublin","sequence":"additional","affiliation":[{"name":"Department of Neurology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360705"},{"key":"atypb2","first-page":"189","volume":"6","author":"Sadovnick AD","year":"1993","journal-title":"Opin Neurol Neurosurg"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198612253152603"},{"key":"atypb4","first-page":"1068","volume":"1","author":"Heltberg A","year":"1982","journal-title":"Lancet"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.8.1039"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320290310"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(93)90035-Y"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1007\/BF02115014"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(93)90163-S"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.54.6.554"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110220"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270311"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.s1-9.34.120"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.27.5.415"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(64)90054-1"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/115.4.979"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.12.2720"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360121"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1995.tb07016.x"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.2.319"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90345-F"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/113.2.419"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(95)00021-S"},{"key":"atypb24","author":"Kalman B","year":"1995","journal-title":"J. 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