{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:24:51Z","timestamp":1790767491505,"version":"4.1.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1997,4,1]],"date-time":"1997-04-01T00:00:00Z","timestamp":859852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[1997,4]]},"abstract":"<jats:p>Studies in both humans and experimental animals indicate that there is potential for full remyelination following CNS demyelination, but the factors that control the degree of myelin repair are unknown. In the Theiler's virus model of demyelination CNS remyelination can be promoted either by global immunosuppression or by selective immunoglobulin therapy. In this paper we discuss whether immunoglobulin-mediated remyelination is a characteristic of immune-mediated demyelination, or whether immunoglobulin-mediated remyelination also occurs in the toxic-traumatic model of lysolecithin-induced demyelination. Our data support the hypothesis that even in a non-primary immune model of demyelination, manipulating the immune system can be beneficial in myelin repair.<\/jats:p>","DOI":"10.1177\/135245859700300203","type":"journal-article","created":{"date-parts":[[2009,11,6]],"date-time":"2009-11-06T19:59:59Z","timestamp":1257537599000},"page":"76-79","source":"Crossref","is-referenced-by-count":9,"title":["Enhancement of central nervous system remyelination in immune and non-immune experimental models of demyelination"],"prefix":"10.1177","volume":"3","author":[{"given":"Baziel GM","family":"van Engelen","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA, Immunology, Mayo Clinic, Rochester, Minnesota, USA, Institute of Neurology, University Hospital Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D","family":"Pavelko","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA, Immunology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA, Immunology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1997,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(73)90118-4"},{"key":"atypb2","first-page":"385","volume":"41","author":"Yajima K.","year":"1979","journal-title":"Lab Invest"},{"key":"atypb3","first-page":"257","volume":"13","author":"Hall SM","year":"1972","journal-title":"J Cell Sci"},{"key":"atypb4","unstructured":"Raine CS, Traugott U. 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