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We compared total intrathecal synthesis of lgA, IgG, and IgM, the number of cells secreting anti-myelin basic protein (MBP) and anti-proteolipid protein (PLP) antibodies of the IgG isotype and intrathecal activation of the complement cascade in patients with possible onset symptoms of MS (n=18) or clinically definite MS (n=30). Early activation of the complement cascade correlated with intrathecal synthesis of IgM. Intrathecal IgG, lgA and IgM synthesis also correlated weakly with the presence of cells secreting anti-MBP or anti-PLP autoantibodies. Full activation of the complement cascade did not correlate with any measures of intrathecal antibody synthesis. These findings suggest a complex relation between different immunoglobulin isotypes and complement activation which may have similarly complex roles in the pathogenesis of MS.<\/jats:p>","DOI":"10.1177\/135245859800400307","type":"journal-article","created":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T20:03:56Z","timestamp":1169150636000},"page":"127-131","source":"Crossref","is-referenced-by-count":41,"title":["MBP, anti-MBP and anti-PLP antibodies, and intrathecal complement activation                 in multiple sclerosis"],"prefix":"10.1177","volume":"4","author":[{"given":"Finn","family":"Sellebjerg","sequence":"first","affiliation":[{"name":"The MS Clinic Department of 1Neurology, Glostrup Hospital, University of                         Copenhagen, Glostrup Copenhagen, Department of Clinical Biochemistry, Sector                         of Diagnostic Services, Statens Serum Institut, 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