{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:39:17Z","timestamp":1790915957848,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1998,12,1]],"date-time":"1998-12-01T00:00:00Z","timestamp":912470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[1998,12]]},"abstract":"<jats:p>We examined cerebra! spinal fluid (CSF) from multiple sclerosis (MS) patients and patients with other neurological diseases (OND) for antibody specific for Human Herpesvirus-6 (HHV-6) and for HHV-6 DNA detectable by PCR. CSF from MS patients had a higher frequency of IgG antibody to HHV-6 late antigens (39.4%) compared with CSF from OND (7.4%). In contrast, the frequency of detectable IgG antibody in CSF from MS patients specific for Epstein-Barr Virus (EBV) (12.1%) and Human Cytomegalovirus (HCMV) (6.1%) was much lower. Two of 12 MS CSFs (16.7%) also contained HHV-6 DNA detected by PCR. None of four OND CSF were positive for HHV-6 DNA. Plasma from 16 patients with MS, eight with OND and 72 healthy donors were tested for antibodies by ELISA to HHV-6 early (p41\/38) and late (gp 110) proteins. Although no differences in ant-gp 110 IgG antibody were detected between MS patients, patients with other neurological diseases, and normals, IgG antibody to early protein p41\/38 was detected in &gt; 68% of the plasma from MS patients, 12.5% from OND patient and 27.8% of the controls. IgM antibody to p41\/38 was present in &gt;56% of MS patients, 12.5% of OND patients, and 19% of controls. These data suggest that more than half of the MS patients had active, ongoing HHV-6 infections. HHV-6 was also isolated from peripheral blood mononuclear cells (PBMC) from 3\/5 MS patients who were in relapse or had progressive disease and was identified as HHV-6 Variant B. These preliminary results support the hypothesis that HHV-6 may be a co-factor in the pathogenesis of some cases of MS.<\/jats:p>","DOI":"10.1177\/135245859800400606","type":"journal-article","created":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T20:03:56Z","timestamp":1169150636000},"page":"490-496","source":"Crossref","is-referenced-by-count":85,"title":["Human Herpesvirus-6 (HHV-6) infection in multiple sclerosis: a preliminary report"],"prefix":"10.1177","volume":"4","author":[{"given":"D V","family":"Ablashi","sequence":"first","affiliation":[{"name":"Advanced Biotechnologies Inc, Columbia, Maryland 21046, Georgetown                         University School of Medicine, Washington, Columbia 20007"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Lapps","sequence":"additional","affiliation":[{"name":"Advanced Biotechnologies Inc, Columbia, Maryland 21046"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kaplan","sequence":"additional","affiliation":[{"name":"North Shore University Hospital, Manhasset, New York 11030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J E","family":"Whitman","sequence":"additional","affiliation":[{"name":"Advanced Biotechnologies Inc, Columbia, Maryland 21046"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J R","family":"Richert","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine, Washington, Columbia 20007"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G R","family":"Pearson","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine, Washington, Columbia 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