{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:41:03Z","timestamp":1777938063720,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1999,6,1]],"date-time":"1999-06-01T00:00:00Z","timestamp":928195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mult Scler"],"published-print":{"date-parts":[[1999,6]]},"abstract":"<jats:p>The limited application of functional magnetic resonance imaging (fMRI) for investigations of multiple sclerosis (MS) patients has already shown that deficits of the motor, cognitive and visual systems may be identified by differences in the patterns of activation in response to a suitable stimulus. In MS patients with unilateral optic neuritis, the area of activation in the primary visual cortex, measured by fMRI techniques, is dramatically reduced in response to stimulation of the affected eye. The latency of the major positive component of the visual evoked potential (VEP) recorded upon stimulation of the affected eye is significantly increased in these patients, as compared to the unaffected eye and normal volunteers. We have found a correlation between the neural response measured using fMRI and the latency of the VEP. fMRI signal responses have the potential to provide more detailed topographic information relating to functional deficits in MS.<\/jats:p>","DOI":"10.1177\/135245859900500304","type":"journal-article","created":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T20:03:56Z","timestamp":1169150636000},"page":"161-164","source":"Crossref","is-referenced-by-count":33,"title":["Reduced visual evoked responses in multiple sclerosis patients with optic                 neuritis: Comparison of functional magnetic resonance imaging and visual evoked potentials"],"prefix":"10.1177","volume":"5","author":[{"given":"P J","family":"Gareau","sequence":"first","affiliation":[{"name":"Robarts Research Institute, 100 Perth Drive, London Health Sciences                         Center, University Campus, London, Ontario, Canada N6A 5K8"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J S","family":"Gati","sequence":"additional","affiliation":[{"name":"Laboratory for Functional Magnetic Resonance Research, London Health                         Sciences Center, University Campus, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R S","family":"Menon","sequence":"additional","affiliation":[{"name":"Robarts Research Institute, 100 Perth Drive, London Health Sciences                         Center, University Campus, London, Ontario, Canada N6A 5K8, Laboratory for                         Functional Magnetic Resonance Research, London Health Sciences Center,                         University Campus, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Nuclear Medicine, London Health                         Sciences Center, University Campus, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of Neurology, London Health Sciences Center, University                         Campus, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Nuclear Medicine, London Health                         Sciences Center, University Campus, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Mandelfino","sequence":"additional","affiliation":[{"name":"Department of Neurology, London Health Sciences Center, University                         Campus, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S J","family":"Karlik","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Nuclear Medicine, London Health                         Sciences Center, University Campus, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1999,6,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5893.661"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.59.5.487"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.2.255"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390104"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.27.1.447"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.24.9868"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.12.5675"},{"key":"atypb8","first-page":"S607","volume":"3","author":"Strupp JP.","year":"1996","journal-title":"Neuro 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