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Although these abnormalities can be detected in other neurological conditions, they seem to be more frequent and diffuse in MS. However, the contribution of NAWM changes to the diagnosis is still unclear. Their nature is also unknown and perhaps differs in different phases and clinical manifestations of the disease. Nevertheless, the extent and severity of NAWM damage seems to be relevant in causing disability and influencing the clinical evolution in MS patients. This review will summarize the present knowledge about MR-detected NAWM changes in MS and their relevance to the diagnosis and the understanding of disease evolution.<\/jats:p>","DOI":"10.1177\/135245859900500414","type":"journal-article","created":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T20:03:56Z","timestamp":1169150636000},"page":"273-282","source":"Crossref","is-referenced-by-count":49,"title":["Normal-appearing white matter changes in multiple sclerosis: the contribution                 of magnetic resonance techniques"],"prefix":"10.1177","volume":"5","author":[{"given":"Massimo","family":"Filippi","sequence":"first","affiliation":[{"name":"Neuroimaging Research Unit, Department of Neuroscience, Scientific                         Institute Ospedale San Raffaele, University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Tortorella","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit, 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