{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:08:59Z","timestamp":1777936139257,"version":"3.51.4"},"reference-count":94,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:p>Subclinical increases in albuminuria (microalbuminuria) predict morbid events, but the reasons for that are still not understood in full. This paper reviews the existing evidence regarding the relationships of non-diabetic microalbuminuria and cardiovascular disease, the underlying assumption being that endothelial dysfunction contributes both to atherosclerotic macrovascular disease and renal microvascular disease of which albuminuria is a marker. Much data support that concept, and suggest a preferential link with endothelial activation in response to acute and subclinical inflammatory stimulation, although further studies are needed to establish the exact cause-effect mechanisms. Epidemiological studies also show associations with cardiovascular events, and some recent prospective results also indicate the power of micro-albuminuria to predict risk independently from conventional atherogenic factors. Thus, micro-albuminuria might be considered as an integrated marker of cardiovascular risk sensitive to systemic vascular status in addition to other parameters such as blood pressure levels, glucose metabolism, smoking habits, a profile rather unique among the prognostic predictors available to stratify risk in hypertensive patients.<\/jats:p>","DOI":"10.1177\/1358836x0100600410","type":"journal-article","created":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T20:21:47Z","timestamp":1169151707000},"page":"257-264","source":"Crossref","is-referenced-by-count":67,"title":["Non-diabetic microalbuminuria, endothelial dysfunction and cardiovascular disease"],"prefix":"10.1177","volume":"6","author":[{"given":"Roberto","family":"Pedrinelli","sequence":"first","affiliation":[{"name":"Dipartimento Cardio Toracico, Universit\u00e0 di Pisa, Pisa, 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