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The timing of the various processes of the ischaemic cascade and the potential time windows for different interventions are better understood. Furthermore, the importance of maintaining cerebral perfusion and optimizing systemic physiological and biochemical factors in order to prevent neurological deterioration (`progressing stroke') is increasingly being realized.<\/jats:p>\n                  <jats:p>Numerous antithrombotic and neuroprotective drugs have been evaluated in clinical trials, and while none has shown unequivocal benefits on its own, prospects for successful intervention are still good. This will probably involve different combinations of treatments targeted on different pathophysiological stroke types, so that the management of acute stroke will offer a considerable challenge to the stroke physicians of the future.<\/jats:p>","DOI":"10.1177\/1358836x9900400306","type":"journal-article","created":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T20:21:47Z","timestamp":1169151707000},"page":"149-163","source":"Crossref","is-referenced-by-count":10,"title":["Neuroprotection in acute ischaemic stroke. 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