{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:42:16Z","timestamp":1792690936654,"version":"4.5.0"},"reference-count":66,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,11,5]],"date-time":"2010-11-05T00:00:00Z","timestamp":1288915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>The \u2018Cardiovascular Continuum\u2019 was described by Dzau and colleagues in 2006 to explain the development over many years of coronary disease with its complications, then end-stage heart failure. The Continuum identified different points along the way where the process could be interrupted by drug therapies or interventions, then described the trials that have been undertaken over the last three decades to establish their value. The approach summarized the major steps in cardiology through modern times, but it had an emphasis on coronary atherosclerosis in prosperous nations, and did not account fully for the problems of aging, which occur in all societies. Aging of the aorta and elastic arteries causes arterial stiffening and leads to development of cardiac failure and microvascular disease in highly perfused organs such as the brain and kidneys. The \u2018Vascular Aging Continuum\u2019 which we introduce, dovetails with the late phases of the Cardiovascular Continuum and provides a more comprehensive explanation, especially for vascular diseases in nations with little atherosclerosis. It will become more common in the Western World where attention to risk factors and widespread use of statins are responsible for a decrease in atherosclerotic disease, prolongation of life, and dominance of macrovascular and microvascular arterial disease, as well as of cardiac failure.<\/jats:p>","DOI":"10.1177\/1358863x10382946","type":"journal-article","created":{"date-parts":[[2010,11,5]],"date-time":"2010-11-05T20:52:07Z","timestamp":1288990327000},"page":"461-468","source":"Crossref","is-referenced-by-count":190,"title":["The Cardiovascular Continuum extended: Aging effects on the aorta and microvasculature"],"prefix":"10.1177","volume":"15","author":[{"given":"Michael F","family":"O'Rourke","sequence":"first","affiliation":[{"name":"St Vincent's Clinic, Victor Chang Cardiac Research Institute and University of New South Wales, Sydney, Australia,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel E","family":"Safar","sequence":"additional","affiliation":[{"name":"Paris Descartes University, Hospital Hotel-Dieu, Diagnosis Center, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Dzau","sequence":"additional","affiliation":[{"name":"Duke University Medical Centre, Duke University, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,11,5]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.655688"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.655761"},{"key":"atypb3","volume-title":"The pressure pulses in the cardiovascular system","author":"Wiggers CJ","year":"1928"},{"key":"atypb4","volume-title":"Circulation of the blood: men and ideas","author":"Fishman AP","year":"1964"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000048892.83521.58"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000048893.62841.F7"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.12.050"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2009.02.008"},{"key":"atypb9","volume-title":"McDonald\u2019s blood flow in arteries: theoretical, experimental and clinical principles","author":"Nichols WW","year":"2005","edition":"5"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.141275"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000168052.00426.65"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00063.2007"},{"key":"atypb13","first-page":"379","volume":"23","author":"Safar ME","year":"2006","journal-title":"Handbook of hypertension"},{"key":"atypb14","unstructured":"Levy D., Brink S. 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