{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:10:36Z","timestamp":1777936236519,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,6,27]],"date-time":"2011-06-27T00:00:00Z","timestamp":1309132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>\n                    Mechanisms underlying the role of lipoprotein-associated phospholipase A\n                    <jats:sub>2<\/jats:sub>\n                    (Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    ) in atherosclerotic development are not completely understood. We evaluated the relationship of Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    with endothelial dysfunction, an early manifestation of atherosclerosis, in a cohort without known clinical cardiovascular disease. A total of 2809 participants in the Multi-Ethnic Study of Atherosclerosis underwent plasma Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    mass and activity measurement and brachial artery flow-mediated vasodilation testing. In adjusted linear regression models, higher Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    mass and activity levels were not associated with lower endothelial function (\u22120.04%, p = 0.51 and \u22120.09%, p = 0.10, respectively). Among individuals with subclinical atherosclerosis based on ankle\u2013brachial index (ABI) or carotid intima\u2013media thickness (IMT), Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    mass and activity were not associated with lower endothelial function (\u22120.03%, p = 0.88 and \u22120.31%, p = 0.16 for ABI &lt; 1.00; 0.01%, p = 0.94 and \u22120.15%, p = 0.20 for abnormal carotid IMT). In summary, Lp-PLA\n                    <jats:sub>2<\/jats:sub>\n                    is not associated with endothelial dysfunction, suggesting its role in atherosclerosis development is primarily related to other factors.\n                  <\/jats:p>","DOI":"10.1177\/1358863x11411360","type":"journal-article","created":{"date-parts":[[2011,6,27]],"date-time":"2011-06-27T22:24:17Z","timestamp":1309213457000},"page":"247-252","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Association of lipoprotein-associated phospholipase A\n                    <sub>2<\/sub>\n                    and endothelial function in the Multi-Ethnic Study of Atherosclerosis (MESA)"],"prefix":"10.1177","volume":"16","author":[{"given":"Parveen K","family":"Garg","sequence":"first","affiliation":[{"name":"Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn L","family":"McClelland","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy S","family":"Jenny","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Vermont College of Medicine, Burlington, VT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Criqui","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, University of California in San Diego School of Medicine, San Diego, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph F","family":"Polak","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tufts Medical Center, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal W","family":"Jorgensen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Cushman","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Vermont College of Medicine, Burlington, VT, USA"},{"name":"Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,6,27]]},"reference":[{"key":"bibr1-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.14.6.671"},{"key":"bibr2-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1042\/bj3380479"},{"key":"bibr3-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115932"},{"key":"bibr4-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.8.2805"},{"key":"bibr5-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2003.08.004"},{"key":"bibr6-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2004.03.001"},{"key":"bibr7-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000052673.77316.01"},{"key":"bibr8-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60319-4"},{"key":"bibr9-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000191655.87296.ab"},{"key":"bibr10-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.864801"},{"key":"bibr11-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.765701"},{"key":"bibr12-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80066-6"},{"key":"bibr13-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000147540.88559.00"},{"key":"bibr14-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf113"},{"key":"bibr15-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000201289.83256.cf"},{"key":"bibr16-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1177\/174182670100800512"},{"key":"bibr17-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.2.197"},{"key":"bibr18-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.12.1333"},{"key":"bibr19-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000154553.12214.CD"},{"key":"bibr20-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.151670"},{"key":"bibr21-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000156457.35971.C8"},{"key":"bibr22-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi010"},{"key":"bibr23-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.160739"},{"key":"bibr24-1358863X11411360","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1997.1570706.x"}],"container-title":["Vascular 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