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The objective of this study was to describe the development, testing, and psychometric properties of the PAD Quality of Life Questionnaire (PADQOL). The PADQOL was developed in three steps: (1) interviews of symptomatic PAD patients provided content of the initial questionnaire; (2) co-administration with the SF-36 (a 36-item short-form health survey), Walking Impairment Questionnaire, and Profile of Mood States examined construct validity; and (3) a three-phased factor analysis identified factors and shortened the questionnaire. Data analyses from 297 symptomatic PAD patients resulted in a 38-item questionnaire of five factors: Social relationships and interactions, Self-concept and feelings, Symptoms and limitations in physical functioning, Fear and uncertainty, and Positive adaptation (\u03b1 = 0.92\u20130.73) and items related to sexual function, intimate relationships and employment. Between-instrument correlations established construct validity. In conclusion, PADQOL is a validated measure to assess the disease-specific physical, psychosocial and emotional effects of PAD for research and practice.<\/jats:p>","DOI":"10.1177\/1358863x12466708","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T06:57:42Z","timestamp":1353913062000},"page":"405-415","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":64,"title":["The PADQOL: Development and validation of a PAD-specific quality of life questionnaire"],"prefix":"10.1177","volume":"17","author":[{"given":"Diane","family":"Treat-Jacobson","sequence":"first","affiliation":[{"name":"University of Minnesota School of Nursing, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth A","family":"Lindquist","sequence":"additional","affiliation":[{"name":"University of Minnesota School of Nursing, Minneapolis, MN, 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