{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:52:26Z","timestamp":1790693546586,"version":"4.1.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T00:00:00Z","timestamp":1431302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Fibromuscular dysplasia (FMD), a non-inflammatory arterial disease, may lead to renovascular hypertension (HTN) and cerebrovascular disease. Little is known about medication use in FMD. Clinical features and medication use were reviewed in a national FMD registry (12 US sites). Medication usage was assessed in raw and adjusted analyses. Covariates included demographic characteristics, co-morbid conditions and vascular bed involvement. A total of 874 subjects (93.6% female) were included in the analysis. Mean age was 55.6\u00b113.1 years, 74.5% had HTN, 25.4% had a history of transient ischemic attack or stroke, and 7.5% had a history of coronary artery disease (CAD). Renal and cerebrovascular arteries were affected in 70.4% and 74.7%, respectively. Anti-platelet agents were administered to 72.9% of patients. In multivariate analyses, factors associated with a greater likelihood of anti-platelet agent use were older age (OR=1.02 per year, p=0.005), CAD (OR=3.76, p=0.015), cerebrovascular artery FMD involvement in isolation (OR=2.31, p&lt;0.0001) or a history of previous intervention for FMD (OR=1.52, p=0.036). A greater number of anti-HTN medications was evident in isolated renal versus isolated cerebrovascular FMD patients. Factors associated with a greater number of anti-HTN medications were older age (OR=1.03 per year, p&lt;0.0001), history of HTN (OR=24.04, p&lt;0.0001), history of CAD (OR=2.71, p=0.0008) and a history of a previous therapeutic procedure (OR=1.72, p=0.001). In conclusion, in FMD, medication use varies based on vascular bed involvement. Isolated renal FMD patients receive more anti-HTN agents and there is greater anti-platelet agent use among patients with cerebrovascular FMD. Further studies correlating medication use in FMD with clinically meaningful patient outcomes are necessary.<\/jats:p>","DOI":"10.1177\/1358863x15584982","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T21:31:22Z","timestamp":1431379882000},"page":"447-453","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Anti-platelet and anti-hypertension medication use in patients with fibromuscular dysplasia: Results from the United States Registry for Fibromuscular Dysplasia"],"prefix":"10.1177","volume":"20","author":[{"given":"Ido","family":"Weinberg","sequence":"first","affiliation":[{"name":"The Fireman Vascular Center, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokui","family":"Gu","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Giri","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Division, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo E","family":"Kim","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Heart and Vascular Institute and the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Bacharach","sequence":"additional","affiliation":[{"name":"North Central Heart Institute, Soux Falls, SD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce H","family":"Gray","sequence":"additional","affiliation":[{"name":"University of South Carolina School of Medicine\/Greenville, Greenville, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry T","family":"Katzen","sequence":"additional","affiliation":[{"name":"Baptist Cardiac and Vascular Institute, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan H","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Vascular Interventional Radiology, University of Virginia Health System, Charlottesville, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Wei","family":"Chi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of California, Davis Medical Center, Sacramento, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R","family":"Rogers","sequence":"additional","affiliation":[{"name":"Cardiology Division, University of Colorado, Denver, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Froehlich","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W","family":"Olin","sequence":"additional","affiliation":[{"name":"Zena and Michael A. Wiener Cardiovascular Institute and Marie-Jos\u00e9 and Henry R. Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather L","family":"Gornik","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Heart and Vascular Institute and the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Jaff","sequence":"additional","affiliation":[{"name":"The Fireman Vascular Center, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,5,11]]},"reference":[{"key":"bibr1-1358863X15584982","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.091223"},{"key":"bibr2-1358863X15584982","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-005-0017-z"},{"key":"bibr3-1358863X15584982","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.01.039"},{"key":"bibr4-1358863X15584982","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.060335"},{"key":"bibr5-1358863X15584982","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103223441206"},{"key":"bibr6-1358863X15584982","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.10.066"},{"key":"bibr7-1358863X15584982","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000349"},{"key":"bibr8-1358863X15584982","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"bibr9-1358863X15584982","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.232"},{"key":"bibr10-1358863X15584982","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7178.257"},{"key":"bibr11-1358863X15584982","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.830299"},{"key":"bibr12-1358863X15584982","unstructured":"US Preventive Services Task Force. 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Available at: www.uspreventiveservicestaskforce.org\/uspstf\/uspsasmi.htm (accessed 10 February 2013)."},{"key":"bibr13-1358863X15584982","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1975.01360110107018"},{"key":"bibr14-1358863X15584982","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000442577.96802.8c"},{"key":"bibr15-1358863X15584982","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2307"},{"key":"bibr16-1358863X15584982","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2302"}],"container-title":["Vascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1358863X15584982","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1358863X15584982","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1358863X15584982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:26:43Z","timestamp":1777692403000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1358863X15584982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,11]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1177\/1358863X15584982"],"URL":"https:\/\/doi.org\/10.1177\/1358863x15584982","relation":{},"ISSN":["1358-863X","1477-0377"],"issn-type":[{"value":"1358-863X","type":"print"},{"value":"1477-0377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,11]]}}}