{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:11:48Z","timestamp":1777936308075,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T00:00:00Z","timestamp":1432771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>\n                    It is unknown how endothelial-dependent flow-mediated dilation (FMD) stimulated by a sustained, exercise-induced increase in shear stress (EX-FMD) is affected by a simultaneous sympathoexcitatory painful stimulus. The purpose of this study was to examine the impact of a cold pressor test (CPT) on brachial artery EX-FMD elicited by a handgrip exercise-induced increase in shear stress. Participants were healthy males (age 21\u00b12 years) ( n=28; 16 Experimental group, 12 Control). Brachial artery diameter and blood velocity were measured using echo and Doppler ultrasound, respectively. Shear stress was estimated by shear rate (shear rate = blood velocity \/ diameter) and targeted to reach 75 s\n                    <jats:sup>\u20131<\/jats:sup>\n                    in each of two EX-FMD trials in all subjects. In the Experimental group, the second EX-FMD trial was accompanied by simultaneous foot immersion in ice water (simultaneous CPT). The shear rate stimulus did not differ between groups ( p=0.823) or trials ( p=0.726) (group \u00d7 trial interaction: p=0.646) (average exercise shear rate (mean \u00b1 SD): 67.6\u00b16.2 s\n                    <jats:sup>\u20131<\/jats:sup>\n                    ). The CPT (experienced during EX-FMD trial 2 in the Experimental group) increased mean arterial pressure ( p&lt;0.001) and heart rate ( p=0.002) relative to the Control group. %EX-FMD was not different between groups ( p=0.508) or trials ( p=0.592) (group \u00d7 trial interaction: p=0.879) (EX-FMD: Experimental group trial 1: 5.4\u00b13.4%, trial 2: 5.6\u00b12.6%; Control group trial 1: 6.0\u00b13.7%, trial 2: 6.4\u00b12.2%). In conclusion, the CPT did not impact concurrent EX-FMD, and this indicates that an acute painful stimulus does not interfere with conduit artery FMD responses during exercise in young healthy men.\n                  <\/jats:p>","DOI":"10.1177\/1358863x15586473","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T21:01:51Z","timestamp":1432846911000},"page":"409-416","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["The impact of a cold pressor test on brachial artery handgrip exercise-induced flow-mediated dilation"],"prefix":"10.1177","volume":"20","author":[{"given":"Troy JR","family":"Stuckless","sequence":"first","affiliation":[{"name":"School of Kinesiology and Health Studies, Queen\u2019s University, Kingston, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyra E","family":"Pyke","sequence":"additional","affiliation":[{"name":"School of Kinesiology and Health Studies, Queen\u2019s University, Kingston, Ontario, 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