{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:39:26Z","timestamp":1790930366083,"version":"4.1.0"},"reference-count":63,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T00:00:00Z","timestamp":1447891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vasc Med"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>Portal vein thrombosis is an unusual thrombotic condition not frequently seen in the general population; however, it has a higher prevalence in special circumstances such as in liver cirrhosis and hepatic or pancreatic malignancy. It also can be associated with significant morbidity and mortality. In this review, we discuss the current data available to guide therapy in the setting of different associated co-morbidities, hypercoagulable states, and associated thrombosis of the remaining splanchnic circulation. We discuss indications for anticoagulation, including the choice of anticoagulants, as well as the role of conservative \u2018wait and watch\u2019 and invasive therapies, such as thrombolysis, thrombectomy, and transjugular intrahepatic portosystemic shunt.<\/jats:p>","DOI":"10.1177\/1358863x15611224","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T17:02:34Z","timestamp":1452531754000},"page":"61-69","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":49,"title":["Portal vein thrombosis: When to treat and how?"],"prefix":"10.1177","volume":"21","author":[{"given":"Aditya M","family":"Sharma","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Virginia, Charlottesville, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Zhu","sequence":"additional","affiliation":[{"name":"Medical Education, University of Virginia, Charlottesville, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Henry","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,11,19]]},"reference":[{"key":"bibr1-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1076688"},{"key":"bibr2-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04454.x"},{"key":"bibr3-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i13.2115"},{"key":"bibr4-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.12.034"},{"key":"bibr5-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.042796"},{"key":"bibr6-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181b3ab44"},{"key":"bibr7-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22105"},{"key":"bibr8-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-01-0040"},{"key":"bibr9-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31301-8"},{"key":"bibr10-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200202000-00019"},{"key":"bibr11-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1996.0053"},{"key":"bibr12-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e31827eea5f"},{"key":"bibr13-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2011.10.003"},{"key":"bibr14-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160515"},{"key":"bibr15-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-08-0526"},{"key":"bibr16-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31826485fc"},{"key":"bibr17-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-196014"},{"key":"bibr18-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22772"},{"key":"bibr19-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2301"},{"key":"bibr20-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(96)00220-6"},{"key":"bibr21-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2010.508464"},{"key":"bibr22-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1198-0"},{"key":"bibr23-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310213"},{"key":"bibr24-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011170"},{"key":"bibr25-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20569"},{"key":"bibr26-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.4.534"},{"key":"bibr27-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04429.x"},{"key":"bibr28-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21231"},{"key":"bibr29-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.08.045"},{"key":"bibr30-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.01.001"},{"key":"bibr31-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12112236"},{"key":"bibr32-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.452"},{"key":"bibr33-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(01)80395-9"},{"key":"bibr34-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02785.x"},{"key":"bibr35-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.07.018"},{"key":"bibr36-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.228023"},{"key":"bibr37-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2008.09.009"},{"key":"bibr38-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1642513"},{"key":"bibr39-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-05-0407"},{"key":"bibr40-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26998"},{"key":"bibr41-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27225"},{"key":"bibr42-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960601)77:11<2217::AID-CNCR6>3.0.CO;2-M"},{"key":"bibr43-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20426"},{"key":"bibr44-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199603000-00011"},{"key":"bibr45-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840120422"},{"key":"bibr46-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000197706.21803.a1"},{"key":"bibr47-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.34.0984"},{"key":"bibr48-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290145"},{"key":"bibr49-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.9603"},{"key":"bibr50-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025313"},{"key":"bibr51-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.1118"},{"key":"bibr52-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-11-0977"},{"key":"bibr53-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.09.019"},{"key":"bibr54-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302507"},{"key":"bibr55-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007903"},{"key":"bibr56-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.004450"},{"key":"bibr57-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1097\/01.ta.0000197354.69796.bd"},{"key":"bibr58-1358863X15611224","first-page":"3358","volume":"118","author":"Bento L","year":"2011","journal-title":"ASH Annual Meeting Abstracts"},{"key":"bibr59-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.674972"},{"key":"bibr60-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.01.012"},{"key":"bibr61-1358863X15611224","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2548-y"},{"key":"bibr62-1358863X15611224","first-page":"867A","volume":"58","author":"Copaci I","year":"2013","journal-title":"Hepatology"},{"key":"bibr63-1358863X15611224","first-page":"894A","volume":"58","author":"Takatori H","year":"2013","journal-title":"Hepatology"}],"container-title":["Vascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1358863X15611224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1358863X15611224","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1358863X15611224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:27:03Z","timestamp":1777692423000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1358863X15611224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,19]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1177\/1358863X15611224"],"URL":"https:\/\/doi.org\/10.1177\/1358863x15611224","relation":{},"ISSN":["1358-863X","1477-0377"],"issn-type":[{"value":"1358-863X","type":"print"},{"value":"1477-0377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,19]]}}}