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CVT encompasses thrombosis of the dural venous sinuses and thrombosis of the cerebral veins. Unusual site VTE often represents a diagnostic and therapeutic challenge because of the heterogeneity in clinical presentation, the limited evidence available in the literature on the acute and long-term prognosis of these diseases, and the lack of large randomized controlled trials evaluating different treatment options. This narrative review describes the approach to patients with SVT or CVT by examining the diagnostic process, the assessment of potential risk factors and the appropriate anticoagulant treatment.<\/jats:p>","DOI":"10.1177\/1358863x17734057","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T00:24:19Z","timestamp":1512433459000},"page":"529-540","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Approach to thrombosis at unusual sites: Splanchnic and cerebral vein thrombosis"],"prefix":"10.1177","volume":"22","author":[{"given":"Nicoletta","family":"Riva","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Malta, Msida, Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Ageno","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Insubria, Varese, 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